Protein Alignment Shawl and twk-7

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_498903.3
• Gene: twk-7 / 192073
• WormBaseID: WBGene00006662
• Length: 557
• Species: Caenorhabditis elegans
• Alignment Length: 549
• Identity: 106/549 - (19%)
• Similarity: 191/549 - (34%)
• Gaps: 156/549 - (28%)

  Fly    13 GIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTGKLHYPTDVC- 76
            |:.|::|:...:.....|::.:.|.            |.|.           :...|.|..||.
 Worm    49 GVEYDSYEELERHEMDDRVTEIPEG------------FHRR-----------QRRNLIYGDDVAT 90

  Fly    77 ---------GPLFEEELEFWGL-------DSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKP 125
                     ..||.||:...||       ||:.:..|   ..|.|.|          :|.|::..
 Worm    91 DEELRVLRREALFGEEVTRAGLGRAEYYEDSHLIHSC---DKSGHED----------IDDESDDE 142

  Fly   126 TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKT 190
            ::::                              ||....||.:..|.:.:..:.: |:..|..|
 Worm   143 SKDE------------------------------DEEEEETGIRKFAKLVLPHVAL-VLLTCTYT 176

  Fly   191 HPG----FRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYT 251
            ..|    :.|:.|                 |:.|.:..|....:    |..:..:....|:
 Worm   177 VIGALIFYSVEQP-----------------HEQMMKEQQLKLIY----TRQNEFVDDLIRL---- 216

  Fly   252 SYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEA 316
              ::||.|...:...:|       :|...|::..:...| |:..|..|..:|:...||:......
 Worm   217 --AAGNETKRYEWESLA-------ERHMHNMSDQLFVAF-EKYFLTSNEVKKNAATETWTFSSSI 271

  Fly   317 FFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGEYTGLLEAFSI 381
            ||.|.:|..:.:...|.:..|  ..:|..:.|   ::....||....|:.:.:.|:  |:..:..
 Worm   272 FFAVTVVTTIGYGNPVPVTNI--GRIWCILFS---LLGIPLTLVTIADLGKFLSEH--LVWLYGN 329

  Fly   382 VRIMRLFKLTRHSPGLRILI----------HTFKASAKELTLLVFFLVLG--IVFFASLAYYAEK 434
            ...::...|:||....|..:          |......|.:..   ||||.  ||:.|.......|
 Worm   330 YLKLKYLILSRHRKERREHVCEHCHSHGMGHDMNIEEKRIPA---FLVLAILIVYTAFGGVLMSK 391

  Fly   435 LQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVI----V 495
            |:  |.:.|.|    .:|:.:||||||:||:.|:....|::..|..:.|:....:.:.::    :
 Worm   392 LE--PWSFFTS----FYWSFITMTTVGFGDLMPRRDGYMYIILLYIILGLAITTMCIDLVGVQYI 450

  Fly   496 SNFSMFYSHTQ-ARSKLPKKRRRVLPVEQ 523
            .....|....| |||.|.....:|:.|.:
 Worm   451 RKIHYFGRKIQDARSALAVVGGKVVLVSE 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	23/118 (19%)
		Ion_trans	307..506	CDD:459842	47/214 (22%)
twk-7	NP_498903.3	Ion_trans_2	<265..321	CDD:462301	11/60 (18%)
		Ion_trans_2	373..>422	CDD:462301	21/54 (39%)