DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shawl and shw-3

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_001355445.1	Gene:	shw-3 / 191761	WormBaseID:	WBGene00004793	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	290/562 - (51%)
Similarity:	362/562 - (64%)	Gaps:	92/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYR 65
            ||.|.||||||.|:|:||||.||||||||||||||..||||||||||||||||||||.|||||||
Worm    22 MDSEYRIILNVGGVRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYR 86

  Fly    66 TGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQI 130
            |||||||.|||||||||||::||||||:.|||||.|.|..||||:.|..||:||||.::....::
Worm    87 TGKLHYPLDVCGPLFEEELKYWGLDSNECEPCCWMTLSGTRDTQDVLKTLDELDIEVDQTEGPEL 151

  Fly   131 ARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFR 195
            .:.||:|:...|..|:.||:|||:||.:||||:||..|:.:|.:||||:..::|.||||||||.|
Worm   152 YKRFGWEDDYHNDSLSAWQKIKPRIWRLFDEPNSSRSAQFIAAISVFFLITAIIVFCLKTHPGLR 216

  Fly   196 VDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTA 260
            :                           |:...:                          |||:.
Worm   217 I---------------------------PELAPF--------------------------GNFSR 228

  Fly   261 SGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCN 325
            :.::|. :.|...|....|.|                             .:||..|.|:|.:||
Worm   229 NHRSTS-SRIHPAQINIDKAN-----------------------------SRPHPTFMYIETICN 263

  Fly   326 VWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGEYTGLLEAFSIVRIMRLFKL 390
            :||.||::.|....|:.::::::||||||..|||:||.|::..|...|..||.|||:||||||||
Worm   264 IWFTIEILARFSSCPSRFEYLRAPVNIIDIVATLTFYIDLLSSMFGATADLEFFSIIRIMRLFKL 328

  Fly   391 TRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIV 455
            |.|:.||:||:|||:||||||.|||||||||:|.||||.||||:::.|.||||.|||:|||||||
Worm   329 THHNSGLKILMHTFRASAKELMLLVFFLVLGVVVFASLVYYAERVESNEDNQFVSIPIGLWWAIV 393

  Fly   456 TMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVLP 520
            ||||:||||:.|.||.|..:|::||||||||||||||||||||:|||||||||||:|||||.||.
Worm   394 TMTTIGYGDITPHTYLGRLIGSICALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLS 458

  Fly   521 VEQPRR--KREPTAPHRGRTNA--IKQTPPTGPGLVAGGVVP 558
            ::|..:  |..|.....|.|..  ::.||     ||:....|
Worm   459 MDQVAQHVKHAPVRNSNGPTQRKNMENTP-----LVSNNHTP 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	79/91 (87%)
		BTB_2	7..97	CDD:280393	77/89 (87%)
		Ion_trans	307..506	CDD:278921	126/198 (64%)
		Ion_trans_2	<449..499	CDD:285168	39/49 (80%)
shw-3	NP_001355445.1	BTB_POZ	25..136	CDD:365784	90/110 (82%)
shw-3	NP_001355445.1	Ion_trans	257..444	CDD:366146	123/186 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I2122
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H84455
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.880