Protein Alignment Shawl and shw-3

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_001355445.1
• Gene: shw-3 / 191761
• WormBaseID: WBGene00004793
• Length: 500
• Species: Caenorhabditis elegans
• Alignment Length: 562
• Identity: 290/562 - (51%)
• Similarity: 362/562 - (64%)
• Gaps: 92/562 - (16%)

  Fly     1 MDGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYR 65
            ||.|.||||||.|:|:||||.||||||||||||||..||||||||||||||||||||.|||||||
 Worm    22 MDSEYRIILNVGGVRHETYKHTLKKIPATRLSRLTTNLANYDPVLNEYFFDRHPGVFAQILNYYR 86

  Fly    66 TGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQI 130
            |||||||.|||||||||||::||||||:.|||||.|.|..||||:.|..||:||||.::....::
 Worm    87 TGKLHYPLDVCGPLFEEELKYWGLDSNECEPCCWMTLSGTRDTQDVLKTLDELDIEVDQTEGPEL 151

  Fly   131 ARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFR 195
            .:.||:|:...|..|:.||:|||:||.:||||:||..|:.:|.:||||:..::|.||||||||.|
 Worm   152 YKRFGWEDDYHNDSLSAWQKIKPRIWRLFDEPNSSRSAQFIAAISVFFLITAIIVFCLKTHPGLR 216

  Fly   196 VDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTA 260
            :                           |:...:                          |||:.
 Worm   217 I---------------------------PELAPF--------------------------GNFSR 228

  Fly   261 SGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCN 325
            :.::|. :.|...|....|.|                             .:||..|.|:|.:||
 Worm   229 NHRSTS-SRIHPAQINIDKAN-----------------------------SRPHPTFMYIETICN 263

  Fly   326 VWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGEYTGLLEAFSIVRIMRLFKL 390
            :||.||::.|....|:.::::::||||||..|||:||.|::..|...|..||.|||:||||||||
 Worm   264 IWFTIEILARFSSCPSRFEYLRAPVNIIDIVATLTFYIDLLSSMFGATADLEFFSIIRIMRLFKL 328

  Fly   391 TRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIV 455
            |.|:.||:||:|||:||||||.|||||||||:|.||||.||||:::.|.||||.|||:|||||||
 Worm   329 THHNSGLKILMHTFRASAKELMLLVFFLVLGVVVFASLVYYAERVESNEDNQFVSIPIGLWWAIV 393

  Fly   456 TMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVLP 520
            ||||:||||:.|.||.|..:|::||||||||||||||||||||:|||||||||||:|||||.||.
 Worm   394 TMTTIGYGDITPHTYLGRLIGSICALAGVLTIALPVPVIVSNFAMFYSHTQARSKMPKKRRGVLS 458

  Fly   521 VEQPRR--KREPTAPHRGRTNA--IKQTPPTGPGLVAGGVVP 558
            ::|..:  |..|.....|.|..  ::.||     ||:....|
 Worm   459 MDQVAQHVKHAPVRNSNGPTQRKNMENTP-----LVSNNHTP 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	90/110 (82%)
		Ion_trans	307..506	CDD:459842	126/198 (64%)
shw-3	NP_001355445.1	BTB_POZ	25..136	CDD:453885	90/110 (82%)
		Ion_trans	248..444	CDD:459842	127/224 (57%)