Protein Alignment Shawl and KCNG3

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_579875.1
• Gene: KCNG3 / 170850
• HGNCID: 18306
• Length: 436
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 153/535 - (28%)
• Similarity: 223/535 - (41%)
• Gaps: 146/535 - (27%)

  Fly     3 GENRIILNVSGIRYETYKATLKKIPATRLSRL---------TEALANYDPVLNEYFFDRHPGVFT 58
            |...::|||.|.||...:..||..|..|:|||         .|...:||...||||||||...|.
Human     7 GAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFG 71

  Fly    59 QILNYYR-TGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCW--------STYSIHRDTQNTLAI 114
            .||.|.| .|||.:...:|...|..|:.:|||:...:|.||.        .||:.:...:..:..
Human    72 FILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSADEPGVLG 136

  Fly   115 LDKLDIENEKPTEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFI 179
            .|:             ||..|.|.|.|...|...:|       .|:||:||..|:|:|.:||.|:
Human   137 RDE-------------ARPGGAEAAPSRRWLERMRR-------TFEEPTSSLAAQILASVSVVFV 181

  Fly   180 FVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPT 244
            .||::..|..|.|.:|    :.|.|...
Human   182 IVSMVVLCASTLPDWR----NAAADNRS------------------------------------- 205

  Fly   245 FRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIET 309
              :.:.:.||:|                                          .||...|
Human   206 --LDDRSRYSAG------------------------------------------PGREPSG---- 222

  Fly   310 YGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRM--GEY 372
                     .:|.:|..||..|.|:|.|||.|..:|:|.|:||||..|...:|..|:..:  ||.
Human   223 ---------IIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGEN 278

  Fly   373 TGLLEA---FSIVRIMRLF---KLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYY 431
            :.|..|   ..::|:||:|   ||.||..||:.|..|.|...:|:.:|:.|:.:.:..|::|:..
Human   279 SQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQL 343

  Fly   432 AEKLQD--NPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVI 494
            .|...|  ..:..|.|||...||.|::||||||||:.|.|.||..:|.:|.::|::.:|||:..|
Human   344 LEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFI 408

  Fly   495 VSNFSMFYSHTQARS 509
            ..:|...|...:.||
Human   409 YHSFVQCYHELKFRS 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	40/101 (40%)
		BTB_2	7..97	CDD:280393	39/99 (39%)
		Ion_trans	307..506	CDD:278921	73/208 (35%)
		Ion_trans_2	<449..499	CDD:285168	22/49 (45%)
KCNG3	NP_579875.1	BTB_POZ_KCNG3	11..122	CDD:349729	41/110 (37%)
		Ion_trans	219..420	CDD:395416	74/213 (35%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	373..378		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820