DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and Kcnq2

DIOPT Version :10

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:XP_038960105.1 Gene:Kcnq2 / 170848 RGDID:621504 Length:937 Species:Rattus norvegicus


Alignment Length:948 Identity:186/948 - (19%)
Similarity:285/948 - (30%) Gaps:296/948 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 PGAGGPPH------GHDPMGEPPQTHQ---YHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQ 263
            ||..|...      |.|| |.|..|..   ....|..|..||:           .|......:|.
  Rat    12 PGTSGEKKLKVGFVGLDP-GAPDSTRDGALLIAGSEAPKRGSV-----------LSKPRTGGAGA 64

  Fly   264 ATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGW---------------------- 306
            ..|           .|||.....|..|:...:     .|..||                      
  Rat    65 GKP-----------PKRNAFYRKLQNFLYNVL-----ERPRGWAFIYHAYVFLLVFSCLVLSVFS 113

  Fly   307 -IETYGQPHEAFFYV-ELVCNVWFFIEVIIRLIVSPNLW---------------QFIKSPVNIID 354
             |:.|.:..|...|: |:|..|.|.:|..:|      :|               :|.:.|..:||
  Rat   114 TIKEYEKSSEGALYILEIVTIVVFGVEYFVR------IWAAGCCCRYRGWRGRLKFARKPFCVID 172

  Fly   355 ---FTATLSFYTDVMQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVF 416
               ..|:::......|.....|..|.:...::|:|:.::.|.....::|.....|.:|||....:
  Rat   173 IMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWY 237

  Fly   417 FLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCAL 481
            ...|.::..:.|.|.|||   ..::.|.:....|||.::|:||:||||..|:|:.|..:.|...|
  Rat   238 IGFLCLILASFLVYLAEK---GENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTL 299

  Fly   482 AGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRR-----------RVLPVEQPRRKREPTAPHR 535
            .||...|||..::.|.|::.... |.|.|..:|||           |.......|.....|..:.
  Rat   300 IGVSFFALPAGILGSGFALKVQE-QHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYY 363

  Fly   536 GRTNAI----KQTPPTGPGLVAGGVVP----------------------------VGAGGPGLG- 567
            .||..:    .||...|    |..::|                            ...|.|..| 
  Rat   364 ERTVTVPMYSSQTQTYG----ASRLIPPLNQLELLRNLKSKSGLTFRKEPQPEPSPSKGRPCRGC 424

  Fly   568 --GHAVGHSAAGAPMFKDAFGGAKIGTVNVNGVNVIGL-HPAQRTTTTMAMAMNEADPTPMSALT 629
              |...|||:....:....|...:       ||...|. .|..:|......|....|.:|...  
  Rat   425 LCGCCPGHSSQKVSLKDRVFSSPR-------GVAAKGKGSPQAQTVRRSPSADQSLDDSPSKV-- 480

  Fly   630 YQVPMLQPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASAAVATAAAAAPAGPSFISSD 694
                   |..........|.......|.||...:..|||.|.      ............|::.|
  Rat   481 -------PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGE------DIVEDNKSCNCEFVTED 532

  Fly   695 Y-----LSVPAV-------------QSLQP-------RAATTGHDFMLPLQPKLLGPLERKDQHP 734
            .     :|:.||             :||:|       ...:.||   |.:..::.....|::..|
  Rat   533 LTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGH---LDMLSRIKSLQSRQEPLP 594

  Fly   735 LQLTAHNLASDTHQLMYSGH----------------AHSQHK----------------------- 760
            :|..........:|..:.||                :..:||                       
  Rat   595 VQSGHEQGPPGQNQAWHKGHQGLGDRIDMIVGPPPPSTPRHKKYPTKGPTAPSRESPQYSPRVDQ 659

  Fly   761 -VGGGAAVLNVPPTLSMSHTQMPPGIASMGQ---------------------RTPNLSFRPAHGA 803
             ||.|..:.:...|...:.|::|...:.||:                     .|..:...||...
  Rat   660 IVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIPPAETE 724

  Fly   804 SSQVATVQQPIPHSHA-----CHASTN-CNIKI--SVASAGL----------SVGCPDEFRTPKV 850
            :...|...:|.|..|:     .||..: |.|||  |.:|.|.          ...||     |..
  Rat   725 AYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRNYAAPPVMPPAQCP-----PST 784

  Fly   851 TLLDDLSDDVNSSTDDCGDCCLVDDSDTYEGTTINNGPSGQENGTEAIGLDD---------GLLD 906
            :..........|...|.|....:.....:| .:::....|....||.:.|:.         .|.|
  Rat   785 SWQQSHQRHGTSPVGDHGSLVRIPPPPAHE-RSLSAYSGGNRASTEFLRLEGTPACRPSEAALRD 848

  Fly   907 ND------GEDEEDGEGSGVG------GDSGDSLGGIY 932
            :|      ..|.|:.|.|..|      .::.|:|...|
  Rat   849 SDTSISIPSVDHEELERSFSGFSISQSKENLDALASCY 886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723
Ion_trans 307..506 CDD:459842 56/217 (26%)
Kcnq2XP_038960105.1 Ion_trans 92..324 CDD:459842 56/241 (23%)
KCNQ_channel 466..719 CDD:460954 40/270 (15%)
KCNQ2_u3 733..821 CDD:465213 19/93 (20%)
KCNQC3-Ank-G_bd 833..933 CDD:463411 12/54 (22%)
Blue background indicates that the domain is not in the aligned region.

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