Protein Alignment Shawl and KCNV2

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_598004.1
• Gene: KCNV2 / 169522
• HGNCID: 19698
• Length: 545
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 136/545 - (24%)
• Similarity: 225/545 - (41%)
• Gaps: 144/545 - (26%)

  Fly     9 LNVSGIRYETYKATLKKIPATRLSRLTEALA---------NYDPVLNEYFFDRHPGVFTQILNYY 64
            :||.|..|:.....|...|.|||.||..:.:         :|:...:||||||.|.||..:.|:|
Human   101 VNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVFQLVYNFY 165

  Fly    65 RTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQ 129
            .:|.|.....:|...|.|||.:||:.......||...:...||     .:.::|.|::|...:.|
Human   166 LSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRD-----ELSERLKIQHELRAQAQ 225

  Fly   130 IARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGF 194
            :...   ||...  ::..:...:.::|.:.::|.||..||.:...|..|:.|||::..|.|
Human   226 VEEA---EELFR--DMRFYGPQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALALNT---- 281

  Fly   195 RVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFT 259
                                           ..:..|||   ..|..||..|
Human   282 -------------------------------VEEMQQHS---GQGEGGPDLR------------- 299

  Fly   260 ASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVC 324
                                              .||.|                     ||::|
Human   300 ----------------------------------PILEH---------------------VEMLC 309

  Fly   325 NVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVM---------QR------MGEYTG 374
            ..:|.:|.::||..:|:|.:|.:|.:|::|..|.|..|..::         ||      :|:...
Human   310 MGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQ 374

  Fly   375 LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNP 439
            :|....::||.|:.||.|||.|||....|.:...:::..|:.|:.:||..|::..|..|  .|.|
Human   375 VLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVE--HDVP 437

  Fly   440 DNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSH 504
            ...|.:||...|||.|:::||||||:.|:|:.|.|...||...|::...:|:.::.:.||.:||.
Human   438 STNFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDYYSK 502

  Fly   505 TQA--RSKLPKKRRRVLPVEQPRRK 527
            .:|  .:.:.::|..|..:::.|:|
Human   503 LKAYEYTTIRRERGEVNFMQRARKK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	33/98 (34%)
		BTB_2	7..97	CDD:280393	32/96 (33%)
		Ion_trans	307..506	CDD:278921	66/213 (31%)
		Ion_trans_2	<449..499	CDD:285168	18/49 (37%)
KCNV2	NP_598004.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	74..93
		BTB	99..190	CDD:321966	31/88 (35%)
		Ion_trans	266..504	CDD:306908	83/345 (24%)
		Selectivity filter. /evidence=ECO:0000250	457..462		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820