DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and Kcnk1

DIOPT Version :10

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_032456.2 Gene:Kcnk1 / 16525 MGIID:109322 Length:336 Species:Mus musculus


Alignment Length:361 Identity:78/361 - (21%)
Similarity:129/361 - (35%) Gaps:108/361 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 FRVTNYTSY-SSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIE 308
            |.|..|..| ..|....|....|...:...:.::|||        .|:||    |....:....:
Mouse    25 FLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKR--------RFLEE----HECLSEPQLEQ 77

  Fly   309 TYGQPHEAFFY-VELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMG-E 371
            ..|:..||..| |.::.|            .|.| |.:        |||:.|.|.:.|:...| .
Mouse    78 FLGRVLEASNYGVSVLSN------------ASGN-WNW--------DFTSALFFASTVLSTTGYG 121

  Fly   372 YTGLL----EAFSI------VRIMRLF------KLTRHSPGLRIL-IHTFKASAKELTLLVFFLV 419
            :|..|    :||.|      :....||      ::|.|.....:| .|.....:|::..:|..::
Mouse   122 HTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRVTVHVTRRPVLYFHIRWGFSKQVVAIVHAVL 186

  Fly   420 LGIV-----FFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAP-KTYPGMF---- 474
            ||.|     ||...|.:: .|:|  |..|..   ..::..::::|:|.||..| :.|...|    
Mouse   187 LGFVTVSCFFFIPAAVFS-VLED--DWNFLE---SFYFCFISLSTIGLGDYVPGEGYNQKFRELY 245

  Fly   475 -VGALC-ALAGVLTIALPVPVIVSNF----------SMFY-------------SHTQARSKLPKK 514
             :|..| .|.|::.:.    |::..|          .|||             .|.|.  .....
Mouse   246 KIGITCYLLLGLIAML----VVLETFCELHELKKFRKMFYVKKDKDEDLVHIMEHDQL--SFSSV 304

  Fly   515 RRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPG 550
            ..:|..:::.:::.||.        ...|:||...|
Mouse   305 TEQVAGLKEEQKQSEPF--------VASQSPPYEDG 332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723
Ion_trans 307..506 CDD:459842 56/252 (22%)
Kcnk1NP_032456.2 Ion_trans_2 <98..157 CDD:462301 16/67 (24%)
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:O00180 117..122 1/4 (25%)
Ion_trans_2 191..267 CDD:462301 19/85 (22%)
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:O00180 225..230 2/4 (50%)
Important for intracellular retention in recycling endosomes. /evidence=ECO:0000250|UniProtKB:O00180 293..299 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..336 6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

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