DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shawl and Kcnd2

DIOPT Version :9

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_062671.1 Gene:Kcnd2 / 16508 MGIID:102663 Length:630 Species:Mus musculus


Alignment Length:741 Identity:201/741 - (27%)
Similarity:305/741 - (41%) Gaps:184/741 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTGKLHY 71
            |:|||||.|::|::.||::.|.|.|.. :|....|.|...:|||||.|.:|..|||:||||||||
Mouse    43 IVLNVSGTRFQTWQDTLERYPDTLLGS-SERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHY 106

  Fly    72 PTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLFGF 136
            |...|...::|||.|:||....:..||:..|. .|..:|...:.|..|.:|..            
Mouse   107 PRHECISAYDEELAFFGLIPEIIGDCCYEEYK-DRRRENAERLQDDADTDNTG------------ 158

  Fly   137 EEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSG 201
            |.||..      ...:.::|..|:.|.:||.|.:...::.|||.||||:..::|.|         
Mouse   159 ESALPT------MTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP--------- 208

  Fly   202 AHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQATP 266
                    .|..| ||                                                 
Mouse   209 --------CGSSP-GH------------------------------------------------- 215

  Fly   267 IATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFFIE 331
            |..:..|:|..:                                     |||.::..|.:.|.:|
Mouse   216 IKELPCGERYAV-------------------------------------AFFCLDTACVMIFTVE 243

  Fly   332 VIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTD-VMQRMGEYTGLLEAFSIVRIMRLFKLTRHSP 395
            .::||..:|:.::|::|.::|||..|.|.:|.. ||....:.:|......:.|:.|:||.:|||.
Mouse   244 YLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQ 308

  Fly   396 GLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTV 460
            |||||.:|.|:.|.||..|:|.|.:.|:.||::.:||||  .:..::|.|||...|:.||||||:
Mouse   309 GLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPAAFWYTIVTMTTL 371

  Fly   461 GYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQ-ARSKLPKKRRRVLPVEQP 524
            ||||:.|||..|...|::|:|:|||.|||||||||||||..|...| |..:..:|:.|:..:.  
Mouse   372 GYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIR-- 434

  Fly   525 RRKREPTAPHRGRTNAIKQTPPTG------------PGLVAGGVVPVGAGGPGLGGH-------A 570
                   |...|..||..|:...|            |..::..    |:.......|       .
Mouse   435 -------AAKSGSANAYMQSKRNGLLSNQLQSSEDEPAFISKS----GSSFETQHHHLLHCLEKT 488

  Fly   571 VGHSAAGAPMFKDAFGGAKIGTVNVNGVNVIGLHPAQRTTTTMAMAMNEADPTPMSALTYQVPML 635
            ..|......:|:::.  .::.|||....:...|...|..|:|.....::.        |:::|  
Mouse   489 TNHEFVDEQVFEESC--MEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKK--------TFRIP-- 541

  Fly   636 QPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASA-AVATAAAAAPAGPSFISSDYLSVP 699
                 .|:..|...|....|............|:.|.:|. |.............::::..:|:|
Mouse   542 -----NANVSGSHRGSVQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIP 601

  Fly   700 AVQSLQPRAATTGHDFMLPLQPKLLG 725
            .    .|.....|.|  .|..|:..|
Mouse   602 T----PPVTTPEGDD--RPESPEYSG 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB 7..99 CDD:197585 43/91 (47%)
BTB_2 7..97 CDD:280393 42/89 (47%)
Ion_trans 307..506 CDD:278921 86/199 (43%)
Ion_trans_2 <449..499 CDD:285168 32/49 (65%)
Kcnd2NP_062671.1 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
Shal-type 3..28 CDD:288455
BTB 43..140 CDD:197585 45/98 (46%)
BTB_2 43..132 CDD:280393 42/89 (47%)
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q63881 71..90 8/18 (44%)
Ion_trans 216..415 CDD:278921 89/237 (38%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 308..321 7/12 (58%)
Ion_trans_2 331..411 CDD:285168 45/81 (56%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 370..375 3/4 (75%)
DUF3399 445..546 CDD:288712 17/121 (14%)
Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000250|UniProtKB:Q63881 474..630 28/171 (16%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 1/14 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..623 7/28 (25%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q63881 627..630
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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