Protein Alignment Shawl and Kcnb1

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_032446.2
• Gene: Kcnb1 / 16500
• MGIID: 96666
• Length: 857
• Species: Mus musculus
• Alignment Length: 979
• Identity: 249/979 - (25%)
• Similarity: 365/979 - (37%)
• Gaps: 320/979 - (32%)

  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVL----------NEYFFDRHPGVFTQI 60
            |:.|||.|:.:|....||.::|.|||.:|.:. ..:|.:|          ||||||||||.||.|
Mouse    32 RVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDC-NTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSI 95

  Fly    61 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKP 125
            ||:||||:||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|..
Mouse    96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELKREAETL 155

  Fly   126 TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKT 190
            .|.:       .|...|   .|....:.|:|.:.::|:||..|||:|.:|:.||.:|.|:..|.|
Mouse   156 RERE-------GEEFDN---TCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNT 210

  Fly   191 HPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSS 255
            .|..:      :.|..|.....|...|
Mouse   211 LPELQ------SLDEFGQSTDNPQLAH-------------------------------------- 231

  Fly   256 GNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYV 320
                                                                            |
Mouse   232 ----------------------------------------------------------------V 232

  Fly   321 ELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLLE 377
            |.||..||.:|.::|.:.||..|:|.|.|:|.||..|.|.:|..:        :.:......:::
Mouse   233 EAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQ 297

  Fly   378 AFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQ 442
            .|.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |..|.:
Mouse   298 IFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDDTK 360

  Fly   443 FKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQA 507
            |||||...|||.:|||||||||:.|||..|..||.||.:||||.||||:|:||:|||.||.. |.
Mouse   361 FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-QK 424

  Fly   508 RSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHAVG 572
            |.:...|||..|    .|.||.                        |.:|.:.
Mouse   425 RQEKAIKRREAL----ERAKRN------------------------GSIVSMN------------ 449

  Fly   573 HSAAGAPMFKDAFGGAKIGTVNV----NGVNVIGLHPAQRTTTTMAMAMNEADPTPMSALTYQVP 633
                    .|||| ...|..:::    ||..|......|
Mouse   450 --------MKDAF-ARSIEMMDIVVEKNGEGVAKKDKVQ-------------------------- 479

  Fly   634 MLQPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASAAVATAAAAAP-AGPSFISSDYLS 697
                     .:|         |.|.....|..| |:.:::|.:..|....:| ...|..|..:|:
Mouse   480 ---------DNH---------LSPNKWKWTKRA-LSETSSSKSFETKEQGSPEKARSSSSPQHLN 525

  Fly   698 VPAVQSLQPRAATT-----------------GHDFMLPLQPKLLGPLERKDQHPLQLTAH----- 740
            |..:|.:..:.|.|                 ..:..:...|..:.||..:.:..:.:.:.
Mouse   526 VQQLQDMYSKMAKTQSQPILNTKEMAPQSQPQEELEMGSMPSPVAPLPTRTEGVIDMRSMSSIDS 590

  Fly   741 --NLASDTHQLMYSGHAHSQHKVGGGAAVLNVPPTLSMSHTQMPPGIASMGQRTPNLSFRPAHGA 803
              :.|:|..:.....|:                |..|:|.       .|.|...|.:.:|.|.||
Mouse   591 FISCATDFPEATRFSHS----------------PLASLSG-------KSGGSTAPEVGWRGALGA 632

  Fly   804 SSQVATVQQPIP---------HSHACHASTNCNIKISVASAGLSVGCPDEFRTPKVTLL----DD 855
            |........|||         .|......|:..:|:.........|.|    ||.:..|    |.
Mouse   633 SGGRLMETNPIPEASRSGFFVESPRSSMKTHNPMKLRALKVNFLEGDP----TPLLPALGLYHDP 693

  Fly   856 LSDDVNSSTDDCG-DCC-LVD------DSDTYEGTTINNGPSGQENGTE-AIGLDDGL---LDND 908
            |.:...::....| :|. |:|      :|..|...:....|...|..|. |...:.|:   :|.|
Mouse   694 LRNRGGAAAAVAGLECASLLDKPVLSPESSIYTTASARTPPRSPEKHTAIAFNFEAGVHQYIDTD 758

  Fly   909 GEDE 912
            .:||
Mouse   759 TDDE 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	44/101 (44%)
		BTB_2	7..97	CDD:280393	43/99 (43%)
		Ion_trans	307..506	CDD:278921	92/206 (45%)
		Ion_trans_2	<449..499	CDD:285168	32/49 (65%)
Kcnb1	NP_032446.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		BTB_POZ_KCNB2	15..141	CDD:349719	47/109 (43%)
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	59..75		3/16 (19%)
		Ion_trans	188..424	CDD:366146	108/346 (31%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	448..481		9/88 (10%)
		Kv2channel	467..678	CDD:367541	43/278 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..569		18/138 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..627		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..802
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..857

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810