DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawl and Kcna6

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_038596.1	Gene:	Kcna6 / 16494	MGIID:	96663	Length:	529	Species:	Mus musculus

Alignment Length:	570	Identity:	182/570 - (31%)
Similarity:	272/570 - (47%)	Gaps:	133/570 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69
            |:::|:||:|:||...||...|.|.|......:..:||:.|||||||:...|..||.||:: |:|
Mouse    42 RLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 106

  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134
            ..|.:|...:|.||:.|:.|....:        :..|:.:..|    ....|:|||...|
Mouse   107 RRPVNVPLDIFMEEIRFYQLGEEAL--------AAFREDEGCL----PEGGEDEKPLPSQ----- 154

  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199
                        .:||   ::|.:|:.|.||..|:.:|.:||..|.:|::.|||:|.|.||.|..
Mouse   155 ------------PFQR---QVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRADGR 204

  Fly   200 SGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQA 264
            .|:::..|.........|:...|...::.: ..||  |||.:|                  :|..
Mouse   205 GGSNEGSGTRLSPASRSHEEEDEDEDSYAF-PGSI--PSGGLG------------------TGGT 248

  Fly   265 TPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFF 329
            :.::|            :.||...                          :.||.||.:|.|||.
Mouse   249 SSLST------------LGGSFFT--------------------------DPFFLVETLCIVWFT 275

  Fly   330 IEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEYT---------------GL 375
            .|:::|....|:...|.::.:||||..|...::    |:::||..:.:               .:
Mouse   276 FELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQSVSGGSGQNGQQAMSLAI 340

  Fly   376 LEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPD 440
            |....:||:.|:|||:|||.||:||..|.:||.:||.||:|||.:|::.|:|..|:||  .|:.|
Mouse   341 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAE--ADDVD 403

  Fly   441 NQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMF---- 501
            :.|.|||...|||:||||||||||:.|.|..|..||:|||:|||||||||||||||||:.|
Mouse   404 SLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRE 468

  Fly   502 --------YSHTQARSKLPKKRRRVLPVEQP-----RRKREPT---APHR 535
                    |:|.......|..:.....:.:|     .|:|.|:   .|||
Mouse   469 TEQEEQGQYTHVTCGQPTPDLKATDNGLGKPDFAEASRERRPSYLPTPHR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	34/92 (37%)
		BTB_2	7..97	CDD:280393	34/90 (38%)
		Ion_trans	307..506	CDD:278921	97/229 (42%)
		Ion_trans_2	<449..499	CDD:285168	37/49 (76%)
Kcna6	NP_038596.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		BTB_POZ_KCNA6	41..170	CDD:349714	47/159 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..238		4/35 (11%)
		Ion_trans	258..468	CDD:366146	95/237 (40%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	360..373		6/12 (50%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	422..427		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..513		4/24 (17%)
		PDZ-binding. /evidence=ECO:0000255	527..529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810