Protein Alignment Shawl and Kcna2

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_032443.3
• Gene: Kcna2 / 16490
• MGIID: 96659
• Length: 499
• Species: Mus musculus
• Alignment Length: 510
• Identity: 169/510 - (33%)
• Similarity: 245/510 - (48%)
• Gaps: 139/510 - (27%)

  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69
            |:::|:||:|:||...||.:.|.|.|....:.:..:||:.|||||||:...|..||.||:: |:|
Mouse    34 RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 98

  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134
            ..|.:|...:|.||:.|:.|....:|        :.|:.:..:.       |.|:|..|
Mouse    99 RRPVNVPLDIFSEEIRFYELGEEAME--------MFREDEGYIK-------EEERPLPE------ 142

  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199
                       |.:||   ::|.:|:.|.||..|:|:|.:||..|.:|::||||:|.|.||.:
Mouse   143 -----------NEFQR---QVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDE-- 191

  Fly   200 SGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQA 264
              ..|.||.|.                 .:|.:|    :.:||         ...|.:||
Mouse   192 --NEDMHGGGV-----------------TFHTYS----NSTIG---------YQQSTSFT----- 219

  Fly   265 TPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFF 329
                                                              :.||.||.:|.:||.
Mouse   220 --------------------------------------------------DPFFIVETLCIIWFS 234

  Fly   330 IEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGE------------YTGLLEAFSIV 382
            .|.::|....|:...|..:.:||||..|.:.::..:...:.|            ...:|....:|
Mouse   235 FEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLV 299

  Fly   383 RIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIP 447
            |:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .|..|:||.|||
Mouse   300 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--ADERDSQFPSIP 362

  Fly   448 LGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFY 502
            ...|||:|:||||||||:.|.|..|..||:|||:|||||||||||||||||:.||
Mouse   363 DAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	35/92 (38%)
		BTB_2	7..97	CDD:280393	35/90 (39%)
		Ion_trans	307..506	CDD:278921	94/208 (45%)
		Ion_trans_2	<449..499	CDD:285168	36/49 (73%)
Kcna2	NP_032443.3	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142	1..125		36/98 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:365784	47/159 (30%)
		Ion_trans	162..420	CDD:395416	120/347 (35%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	312..325		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142	497..499

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810