DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shawl and Kcnd1

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_001099218.1	Gene:	Kcnd1 / 116695	RGDID:	621364	Length:	650	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	207/741 - (27%)
Similarity:	289/741 - (39%)	Gaps:	215/741 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTG 67
            |:..:::||||.|:||:|.||.:.|.|.|.. :|....||....||||||.|.:|..:||:||||
  Rat    38 GDEVLVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDAESGEYFFDRDPDMFRHVLNFYRTG 101

  Fly    68 KLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIAR 132
            :||.|...|...|:|||.|:||....|..||...|   ||.:                 :|...|
  Rat   102 RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEY---RDRK-----------------KENAER 146

  Fly   133 LFGFEEALSNGE---LNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGF 194
            |...|||...||   |.....::.::|..|:.|.:||.|.:...::.|||.||||:..::|.|
  Rat   147 LAEDEEAEQAGEGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP-- 209

  Fly   195 RVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFT 259
                      ..||...            |...|        |.|...||
  Rat   210 ----------CRGPARW------------PTKEQ--------PCGDRFPT--------------- 229

  Fly   260 ASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVC 324
                                                                    |||.::..|
  Rat   230 --------------------------------------------------------AFFCMDTAC 238

  Fly   325 NVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV-MQRMGEYTGLLEAFSIVRIMRLF 388
            .:.|..|.::||..:|:..:|::|.:::||..|.|.:|..: :.:..:.:|......:.|:.|:|
  Rat   239 VLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLFVPKNDDVSGAFVTLRVFRVFRIF 303

  Fly   389 KLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWA 453
            |.:|||.|||||.:|.|:.|.||..|:|.|.:.|:.||::.:||||  ......|.|||...|:.
  Rat   304 KFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GTSKTNFTSIPAAFWYT 366

  Fly   454 IVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRV 518
            ||||||:||||:.|.|..|...|::|:|:|||.|||||||||||||..|...|...|     ||
  Rat   367 IVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADK-----RR- 425

  Fly   519 LPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAG-GPGL-----------GGHAV 571
              .:|..|.........|.|||..|....      ||:...|:| |..|           ..|.:
  Rat   426 --AQQKVRLARIRLAKSGTTNAFLQYKQN------GGLEDSGSGEGQMLCVRSRSAFEQQHHHLL 482

  Fly   572 G-------HSAAGAPMFKDAFGGAKIG--TVNVNGVNVIGLHP-------------------AQR 608
            .       |.......|.:|.|...:|  |.....|:...:.|                   |..
  Rat   483 HCLEKTTCHEFTDELTFSEALGAVSLGGRTSRSTSVSSQPMGPGSLFSSCCSRRGERRAIRLANS 547

  Fly   609 TTTTMAMAMNEAD--------PTPMS----------------------ALTYQVPMLQPTPTPAH 643
            |.:....:|.|.|        |.|.|                      |....:| ..|..||..
  Rat   548 TASVSRGSMQELDTLAGLRRSPAPQSRSSLNAKPHDSLDLNCESRDFVAAIISIP-TPPANTPDE 611

  Fly   644 SHGHAHGHAHGLGPASAAMTSSASLT 669
            |...:.|.....|.|:..:.:|:..|
  Rat   612 SQPSSPGGGGSGGMANTTLRNSSLAT 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	43/91 (47%)
		BTB_2	7..97	CDD:280393	42/89 (47%)
		Ion_trans	307..506	CDD:278921	82/199 (41%)
		Ion_trans_2	<449..499	CDD:285168	31/49 (63%)
Kcnd1	NP_001099218.1	BTB_POZ	6..143	CDD:365784	48/125 (38%)
		Ion_trans	185..417	CDD:395416	100/336 (30%)
		DUF3399	447..550	CDD:403174	18/108 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810