DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawl and Kcnq3

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_690887.2	Gene:	Kcnq3 / 110862	MGIID:	1336181	Length:	873	Species:	Mus musculus

Alignment Length:	391	Identity:	74/391 - (18%)
Similarity:	135/391 - (34%)	Gaps:	76/391 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 GPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQATPIATIK 271
            |.|.||.....:|.|.........:..:....|.:..........:...|.....|
Mouse    17 GEGGGGGGGAANPAGGDSAVAGDEERKVGLAPGDVEQVTLALGAGADKDGTLLLEG--------- 72

  Fly   272 GGQRQRLKRNIN--GSILNEFIEEKILGHNGR-------------RKHGWIETYGQPHEAFFYVE 321
            ||:.:..:|...  |.:....:...:..:|.:             |..||...|   |...|.:.
Mouse    73 GGREEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLY---HALVFLIV 134

  Fly   322 LVCNV----------------WFFIEVIIRLIV-----SPNLW---------------QFIKSPV 350
            |.|.:                |..:.....:.:     :..:|               :|.:.|:
Mouse   135 LGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPL 199

  Fly   351 NIID-FTATLSFYTDVMQRMGEYTGL-LEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTL 413
            .::| |....|.....:...|..... |.:...::|:|:.::.|.....::|.....|.:|||..
Mouse   200 CMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELIT 264

  Fly   414 LVFFLVLGIVFFASLAYYAEKLQDNPD---------NQFKSIPLGLWWAIVTMTTVGYGDVAPKT 469
            ..:...|.::..:.|.|..||  |.|:         .:|::....|||.::|:.|:||||..|||
Mouse   265 AWYIGFLTLILSSFLVYLVEK--DVPEMDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKT 327

  Fly   470 YPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVLPVEQPRRKREPTAPH 534
            :.|..:.|..:|.||...|||..::.|..::.......:....|:|:....:.|...:...|.|:
Mouse   328 WEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPN 392

  Fly   535 R 535
            |
Mouse   393 R 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585
		BTB_2	7..97	CDD:280393
		Ion_trans	307..506	CDD:278921	51/245 (21%)
		Ion_trans_2	<449..499	CDD:285168	21/49 (43%)
Kcnq3	NP_690887.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		6/23 (26%)
		Ion_trans	140..364	CDD:278921	46/225 (20%)
		Ion_trans_2	270..354	CDD:285168	28/85 (33%)
		Selectivity filter. /evidence=ECO:0000250	317..322		3/4 (75%)
		Mediates interaction with calmodulin. /evidence=ECO:0000250\|UniProtKB:O43525	357..538		6/37 (16%)
		KCNQ_channel	453..657	CDD:281513
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	723..742
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..873
		KCNQC3-Ank-G_bd	781..867	CDD:288784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810