DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shawl and kcnc4

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	XP_002933043.1	Gene:	kcnc4 / 100492941	XenbaseID:	XB-GENE-6032635	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	221/563 - (39%)
Similarity:	304/563 - (53%)	Gaps:	120/563 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GEN--RIILNVSGIRYETYKATLKKIPATRLSRL----TEALANYDPVLNEYFFDRHPGVFTQIL 61
            ||:  :|.:||.|.|:||||:||:.:|.|||:.|    |.:.:..|....|:|||||||:|:.:|
Frog    32 GEDSGKITINVGGTRHETYKSTLRTLPGTRLAWLADPDTASNSESDSQRTEFFFDRHPGIFSYVL 96

  Fly    62 NYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIEN-EKP 125
            |||||||||.|.|:|||||||||.|||:|...||||||.||..|||.:..|.|.:.::.|: |:.
Frog    97 NYYRTGKLHCPADICGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFENVEPEDGEEE 161

  Fly   126 TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKT 190
            .:.....|...||...... .||:..:||:||:|::|.||..|::||.:|:|||.:|:.:|||:|
Frog   162 NKGSSPELLCIEERTDRSR-GCWKVWQPKMWALFEDPYSSRAARVVAFVSLFFILMSITTFCLET 225

  Fly   191 HPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSS 255
            |..|.||                                         .::..|..:.|.|..
Frog   226 HESFIVD-----------------------------------------RNVTETVTIGNMTEI-- 247

  Fly   256 GNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYV 320
                                         .::.|...|.||                     .|:
Frog   248 -----------------------------LVVREVETEPIL---------------------TYI 262

  Fly   321 ELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV------MQRMGEYTGLLEAF 379
            |.||..||.:|.::|:|..|:...|:|:.:|||||.|.|.||.:|      .:...:..|.|...
Frog   263 EGVCVFWFTLEFLVRIICCPDKVFFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVV 327

  Fly   380 SIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDN--- 441
            ..|||:|:||||||..|||:|.||.:||..|..||:.||.||::.||::.||||::..||.:
Frog   328 RFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGANPTDPSG 392

  Fly   442 ----QFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFY 502
                .||:||:|.|||:|||||:||||:.|:|:.||.||||||||||||||:||||||:||.|:|
Frog   393 SNHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 457

  Fly   503 SHTQARSKLPKKRRRVLPV-----EQPRRKREPTAPHRGRTNA 540
            |...|:.|||||:::.:|.     .|...|.|..: ||..|.:
Frog   458 SLAMAKQKLPKKKKKHVPKTSQMDSQTTLKSEDNS-HRNSTQS 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	56/95 (59%)
		BTB_2	7..97	CDD:280393	54/93 (58%)
		Ion_trans	307..506	CDD:278921	103/211 (49%)
		Ion_trans_2	<449..499	CDD:285168	38/49 (78%)
kcnc4	XP_002933043.1	Potassium_chann	1..29	CDD:314363
		BTB_POZ	34..150	CDD:365784	64/115 (56%)
		Ion_trans	203..461	CDD:366146	126/350 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2104
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1532
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11537
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160