DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawl and kcnb1

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	XP_031750650.1	Gene:	kcnb1 / 100489405	XenbaseID:	XB-GENE-982937	Length:	875	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	182/538 - (33%)
Similarity:	251/538 - (46%)	Gaps:	145/538 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSR---------LTEALANYDPVLNEYFFDRHPGVFTQIL 61
            |:.|||.|:.:|....||.::|.|||.:         |.|...:|:...||||||||||.||.||
Frog    32 RVKLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHECLMEICDDYNLEENEYFFDRHPGAFTSIL 96

  Fly    62 NYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPT 126
            |:|||||||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|...
Frog    97 NFYRTGKLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELKREAETLR 156

  Fly   127 EEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTH 191
            |.:       .|...|   .|....:.|:|.:.::|:||..|||:|.:|:.||.:|.|:..|.|.
Frog   157 ERE-------GEEFDN---TCCADKRKKLWDLLEKPNSSVAAKILAIISILFIVLSTIALSLNTL 211

  Fly   192 PGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSG 256
            |    ||                .|.|..|:.....|
Frog   212 P----DL----------------QGIDEFGQTTDNPQ---------------------------- 228

  Fly   257 NFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVE 321
                                                   |.|                     ||
Frog   229 ---------------------------------------LAH---------------------VE 233

  Fly   322 LVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLLEA 378
            .||..||.:|.::|.:.|||.|:|.|.|:|:||..|.|.:|..:        :.:......:::.
Frog   234 AVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQI 298

  Fly   379 FSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQF 443
            |.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |..|.:|
Frog   299 FRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEEDTKF 361

  Fly   444 KSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQAR 508
            ||||...|||.:|||||||||:.|||..|..||.||.:||||.||||:|:||:|||.||.. |.|
Frog   362 KSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-QKR 425

  Fly   509 SKLPKKRRRVLPVEQPRR 526
            .:...|||..|  |:.:|
Frog   426 QEKAIKRREAL--ERAKR 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	45/100 (45%)
		BTB_2	7..97	CDD:280393	44/98 (45%)
		Ion_trans	307..506	CDD:278921	93/206 (45%)
		Ion_trans_2	<449..499	CDD:285168	32/49 (65%)
kcnb1	XP_031750650.1	BTB_POZ_KCNB2	15..141	CDD:349719	48/108 (44%)
		Ion_trans	188..424	CDD:395416	113/346 (33%)
		Kv2channel	467..720	CDD:397541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000