Protein Alignment Shawl and kcnd1

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_001119942.1
• Gene: kcnd1 / 100001681
• ZFINID: ZDB-GENE-081105-40
• Length: 632
• Species: Danio rerio
• Alignment Length: 559
• Identity: 169/559 - (30%)
• Similarity: 243/559 - (43%)
• Gaps: 150/559 - (26%)

  Fly     1 MDGENR----IILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQIL 61
            :|.:||    :.:||||:|::|:|.||.:.|.|.|.. :|....|:....||||||.|.:|..||
Zfish    32 IDKKNRNDEILFVNVSGLRFQTWKNTLDRYPDTLLGS-SEKEFFYNEDTQEYFFDRDPEMFRHIL 95

  Fly    62 NYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTY-SIHRDTQNTLAILDKLDIENEKP 125
            |:||||:||||...|...|:|||.|:|:..:.:..||...| ...::.|..||:    |.|.|..
Zfish    96 NFYRTGRLHYPRQECIQAFDEELAFYGIVPDIIGDCCMEEYRDRKKENQERLAV----DTEAEMA 156

  Fly   126 TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKT 190
            |:..:.......|               ::|..|:.|.:||.|.:...::.|||.||||:..::|
Zfish   157 TDTPLPPHSTHRE---------------RLWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVET 206

  Fly   191 HP-----GFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNY 250
            .|     |.:.|||.|
Zfish   207 VPCRPLKGSKKDLPCG------------------------------------------------- 222

  Fly   251 TSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHE 315
                                                                     |.|..
Zfish   223 ---------------------------------------------------------EKYSL--- 227

  Fly   316 AFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTD-VMQRMGEYTGLLEAF 379
            |||.::..|.:.|..|.::||..:|:..:|::|.:::||..|.:.:|.. ||....:.:|.....
Zfish   228 AFFCMDTACVLIFTFEYLMRLFAAPSRCKFMRSVMSVIDVVAIMPYYIGLVMPENEDVSGAFVTL 292

  Fly   380 SIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFK 444
            .:.|:.|:||.:|||.|||||.:|.|:.|.||..|:|.|.:.|:.||::.:||||  ......|.
Zfish   293 RVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GTKGTNFT 355

  Fly   445 SIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARS 509
            |||...|:.||||||:||||:.|.|..|...|::|:|:|||.|||||||||||||..|...|...
Zfish   356 SIPASFWYTIVTMTTLGYGDMVPNTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRAD 420

  Fly   510 KLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTG 548
            |        :..:|..|........:|.|||..|....|
Zfish   421 K--------MRAQQKVRLARIRLAKKGTTNAFLQYKEEG 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	41/91 (45%)
		BTB_2	7..97	CDD:280393	40/89 (45%)
		Ion_trans	307..506	CDD:278921	85/199 (43%)
		Ion_trans_2	<449..499	CDD:285168	31/49 (63%)
kcnd1	NP_001119942.1	Shal-type	3..28	CDD:288455
		BTB_2	42..131	CDD:280393	40/89 (45%)
		BTB	44..132	CDD:197585	40/88 (45%)
		Ion_trans	217..415	CDD:278921	89/308 (29%)
		Ion_trans_2	331..411	CDD:285168	44/81 (54%)
		DUF3399	445..542	CDD:288712	2/7 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810