DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and DSCAML1

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_011541219.1	Gene:	DSCAML1 / 57453	HGNCID:	14656	Length:	2065	Species:	Homo sapiens

Alignment Length:	588	Identity:	122/588 - (20%)
Similarity:	191/588 - (32%)	Gaps:	185/588 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITYTDNTW 108
            |...:.:.|:|...|||..:.|.|.....|.:.| :.|..::...||.|:         :.:.|.
Human   517 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKW-YKDALLLPDNHRQVV---------FENGTL 571

  Fly   109 LLHVNQAHQDDRGYYMCQVNTNPM--ISQVGYLQVVVPPNILDIESTP----------------- 154
            .|...|...|: |.|:|.|...|.  |||..::.|.|||.|...|..|
Human   572 KLTDVQKGMDE-GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGD 635

  Fly   155 ---------------------------------SSVAVRENQNIN-------------------- 166
                                             |||:::.|.|..
Human   636 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 700

  Fly   167 --------------------MTCRADGFPAPKIIWRREDGEEIAVEKKKKVLVYDADVLP----- 206
                                :.|..||:|.||::|:...|.....:.....|.....:||
Human   701 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLL 765

  Fly   207 LTKVSRNEMGAYLCIATNGVPPSVSKRIILDVEFSPMIWV-PNQLVGAPSGTDVTIDCHTEAHPK 270
            :..|...::|.|||.|:|||...:||.:.|.|:...||.. ||..: |..|....::|.......
Human   766 IRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTI-AIKGHAKELNCTARGERP 829

  Fly   271 AIIYWVYNSVMVLPSK--KYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRV 333
            .||.|.....::.|.:  :|.....:|.......|.::....||...:.|.:.||.||..|.|::
Human   830 IIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQL 894

  Fly   334 YEIPLPSTPSKQVTHTTVESRENNIIPSSRND-----------------------TTKSLQTDVG 375
            .....|..|..::..  |::|..|:..:.|.|                       :|:::...:.
Human   895 TVQEPPDPPELEIRE--VKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTIN 957

  Fly   376 YAMKNDLYPGSA------SSSSSGGSSSAASSSSSMQTSA------------------------- 409
            .|...||:|.|.      |.:..|.|..:...:.|.:.:|
Human   958 QANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAP 1022

  Fly   410 ---LPGGV-----AGNSLSSMGSKGSLAI------GKSTFYTERPPNEYAASSVAGLLLHRALLF 460
               |..||     .|...:|.||.|..:|      |.|..||.....::|...|.....:||
Human  1023 KKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRA--- 1084

  Fly   461 GSG 463
            |:|
Human  1085 GTG 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	26/93 (28%)
		Ig	145..238	CDD:416386	32/187 (17%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	4/54 (7%)
		Ig strand B	165..172	CDD:409353	1/46 (2%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	2/10 (20%)
		Ig strand F	216..223	CDD:409353	4/6 (67%)
		Ig strand G	230..238	CDD:409353	3/7 (43%)
		Ig	242..333	CDD:416386	23/93 (25%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	3/4 (75%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	2/9 (22%)
		Ig strand F	314..322	CDD:409353	1/7 (14%)
		Ig strand G	325..334	CDD:409353	4/8 (50%)
DSCAML1	XP_011541219.1	IG_like	43..119	CDD:214653
		IGc2	43..110	CDD:197706
		Ig	125..218	CDD:299845
		IG_like	137..209	CDD:214653
		I-set	245..323	CDD:254352
		IGc2	252..313	CDD:197706
		IGc2	340..401	CDD:197706
		I-set	420..514	CDD:254352
		Ig	420..510	CDD:299845
		IGc2	531..589	CDD:197706	18/68 (26%)
		IG_like	619..698	CDD:214653	5/78 (6%)
		Ig	627..693	CDD:143165	5/65 (8%)
		I-set	702..797	CDD:254352	23/94 (24%)
		Ig7_DSCAM	719..797	CDD:143211	23/77 (30%)
		I-set	803..896	CDD:254352	22/93 (24%)
		Ig	815..903	CDD:299845	19/87 (22%)
		FN3	899..993	CDD:238020	16/95 (17%)
		FN3	1000..1097	CDD:238020	19/91 (21%)
		fn3	1105..1191	CDD:278470
		FN3	1203..1294	CDD:238020
		IGc2	1318..1382	CDD:197706
		FN3	1396..1486	CDD:238020
		FN3	1500..1572	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910