DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and SDK2

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens

Alignment Length:	483	Identity:	97/483 - (20%)
Similarity:	175/483 - (36%)	Gaps:	118/483 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 MMDEPRFA-QPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITY 103
            :::.|:|. :|..::|..:.:..::||..:.:....:.| :.|..::      .:.::.|:.
Human   304 VLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW-YKDAAVV------EVEKLTRFR--- 358

  Fly   104 TDNTWLLHVNQAHQDDRGYYMC-------QVNTNPMISQVGYLQVV-VPPNIL--DIESTPSSVA 158
            ..|...|.::....||.|.:.|       :|.|:.      ||.|. :.|||.  .::||
Human   359 QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTST------YLAVTSIAPNITRGPLDST----- 412

  Fly   159 VRENQNINMTCRADGFPAPKIIWRREDGEEIAVE---KKKKVLVYDADVLPLTKVSRNEMGAYLC 220
            |.:..::.:.|...|.|.|.|.|::  ||.|...   :..:....::..|.::....::.|.|.|
Human   413 VIDGMSVVLACETSGAPRPAITWQK--GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTC 475

  Fly   221 IATNGVPPSVSKRIILDVEFSPMIWVPNQLVGAP------SGTDVTIDCHTEAHPKAIIYWVYNS 279
            :|||       .|.:.:.....::|...::...|      .||..::.|.....|:..|.:::
Human   476 LATN-------SRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIW-- 531

  Fly   280 VMVLPSKKYKTDYTENSYRAHM----KLTIRNLQYGDFGNYRC--ISKNSLGETEGSIRVYEIPL 338
                 .|...|..||:..|..:    .|.|.....||.|.|.|  ||..........:||.:  |
Human   532 -----EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQ--L 589

  Fly   339 PSTPSKQV-THTTVESR------------------------ENN---------IIPSSRNDTTKS 369
            |..|...| |.:|||.|                        |||         :.|.:.:.|.|.
Human   590 PHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKG 654

  Fly   370 LQTDVGYAMK----NDLYPGSASSSSSGGSSSAASSSSSMQTSALPGGVAGNSLSSMGSKGSLAI 430
            |.....|..:    ||:..|..|..:...|......::..|          |.::|..:..|:.|
Human   655 LVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQ----------NVIASGRTNQSIMI 709

  Fly   431 GKSTFYTERPPNEYAASSVAGLLLHRAL 458
                 ..:.||..:....:.|.::...|
Human   710 -----QWQPPPESHQNGILKGYIIRYCL 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	17/99 (17%)
		Ig	145..238	CDD:416386	23/97 (24%)
		Ig strand A	145..149	CDD:409353	3/5 (60%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	1/7 (14%)
		Ig	242..333	CDD:416386	21/102 (21%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	2/13 (15%)
		Ig strand F	314..322	CDD:409353	5/9 (56%)
		Ig strand G	325..334	CDD:409353	1/8 (13%)
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352
		Ig	132..210	CDD:299845
		IG_like	222..304	CDD:214653	97/483 (20%)
		IGc2	233..286	CDD:197706
		I-set	308..397	CDD:254352	19/104 (18%)
		Ig	326..394	CDD:143165	13/83 (16%)
		I-set	402..492	CDD:254352	23/103 (22%)
		Ig	416..492	CDD:299845	17/84 (20%)
		Ig	502..586	CDD:299845	20/90 (22%)
		IG_like	502..586	CDD:214653	20/90 (22%)
		FN3	590..681	CDD:238020	20/90 (22%)
		FN3	693..786	CDD:238020	9/55 (16%)
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810