DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and NCAM2

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	457	Identity:	102/457 - (22%)
Similarity:	171/457 - (37%)	Gaps:	90/457 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LIYMTNLVTHVMMDEPRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVI 93
            :|.:.|:...:.|.:..|     |.|...|.:....|.........::|..         :..:|
Human   226 IIVIVNVPPAISMPQKSF-----NATAERGEEMTFSCRASGSPEPAISWFR---------NGKLI 276

  Fly    94 SRIPRYSITYTDNTWLLHVNQAHQDDRGYYMCQ-VNTNPMISQVGYLQVVVPPNILDIESTPSSV 157
            ....:| |....||.|. |......|.|.|:|: .|......:..:|||.|.|:|:.:::.
Human   277 EENEKY-ILKGSNTELT-VRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNE---- 335

  Fly   158 AVRENQNINMTCRADGFPAPKIIWRRE-------------DGEEIAVEKKKKVLVYDADVLPLTK 209
            ...||..:.:.|.|:|.|.|:|.|:|.             ||.   :|.|.:   :.:..|.:..
Human   336 TTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGR---IEVKGQ---HGSSSLHIKD 394

  Fly   210 VSRNEMGAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQLV-GAPSGTDVTIDCHTEAHPKAII 273
            |..::.|.|.|.|.:.: ....|.:.||:|::|. ::.||.: .:..|..:.|.|..:::|.|.|
Human   395 VKLSDSGRYDCEAASRI-GGHQKSMYLDIEYAPK-FISNQTIYYSWEGNPINISCDVKSNPPASI 457

  Fly   274 YWVYNSVMVLPSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPL 338
            :| ....:|||:|. .|:....|....|.|.|......|||.|.|.:.|.:|.   ..:.|.:.|
Human   458 HW-RRDKLVLPAKN-TTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGT---RFQEYILAL 517

  Fly   339 PSTPSK-------QVTHTTVESRENNIIPSSRNDT-TKSLQTDVGYAMKNDLYPGSASSSSSGGS 395
            ...||.       :::.||.:...|.  |.|.... ....|.||
Human   518 ADVPSSPYGVKIIELSQTTAKVSFNK--PDSHGGVPIHHYQVDV--------------------- 559

  Fly   396 SSAASS------SSSMQTSALPGGVAGNS-----LSSMGSKGSLAIGKSTFYTERPPNEYAASSV 449
            ...||.      |..:||..:...:..|:     ::::..||.....|...:...|..|.:..|:
Human   560 KEVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSI 624

  Fly   450 AG 451
            .|
Human   625 HG 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	20/92 (22%)
		Ig	145..238	CDD:416386	24/105 (23%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	1/1 (100%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	2/7 (29%)
		Ig	242..333	CDD:416386	26/91 (29%)
		Ig strand A'	250..253	CDD:409353	0/3 (0%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	2/4 (50%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	3/9 (33%)
		Ig strand F	314..322	CDD:409353	3/7 (43%)
		Ig strand G	325..334	CDD:409353	1/8 (13%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274
		I-set	47..136	CDD:254352
		I-set	142..218	CDD:254352
		IGc2	153..214	CDD:197706
		Ig	233..326	CDD:299845	22/108 (20%)
		I-set	240..323	CDD:254352	19/98 (19%)
		Ig5_NCAM-2	325..422	CDD:143278	25/107 (23%)
		IG_like	333..420	CDD:214653	21/97 (22%)
		IG_like	438..515	CDD:214653	24/81 (30%)
		IGc2	439..507	CDD:197706	22/69 (32%)
		FN3	521..613	CDD:238020	19/114 (17%)
		fn3	619..703	CDD:278470	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910