DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and negr1

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	305	Identity:	86/305 - (28%)
Similarity:	131/305 - (42%)	Gaps:	53/305 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GRDANLPCVVEHLGGY-KVAWIHIDRQMILTIHRHVISRIPRYSITYT---DNTWLLHVNQAHQD 118
            |..|.|.|.:  |.|. |.||  ::|..|:.......|..||.||...   .:.:.|.:.:....
Zfish    52 GDTALLRCYL--LDGISKGAW--LNRSSIIYAGNDKWSGDPRVSIVSNVGDKHEYSLQIQKVDVT 112

  Fly   119 DRGYYMCQV----NTNPMISQVGYLQVVVPPNILDIESTPSSVAVRENQNINMTCRADGFPAPKI 179
            |.|.|.|.:    |.:|.:.|   |.|.|||.|.||.   |.:.|.|..|:::.|.|.|.|.|||
Zfish   113 DEGVYTCSIQSERNLHPKLIQ---LIVKVPPKIYDIS---SDITVNEGSNVSLICAASGKPEPKI 171

  Fly   180 IWRREDGEEIAVEKKKKVLVYDA-DVLPLTKVSRNEMGAYLCIATNGVPPSVSKRIILDVEFSPM 243
            .||     .|:...:|    |:: :.|.:|.:||::.|.|.|.|.|.:....:|.:.:.|.|.|.
Zfish   172 SWR-----HISPSARK----YESGEYLNITGISRDQAGDYECGAENDIASPDTKTVRVTVNFPPA 227

  Fly   244 IWVPNQLV--GAPSGTDVTIDCHTEAHPKAIIYWVYNSVMVLPSKKYKTD--------YTENSYR 298
            |   :::.  |...|....:.|...|.|..:..|            ||.:        ...|:..
Zfish   228 I---HEMKSHGVRPGQVALLRCEAAAVPSPVFEW------------YKGEKRINMGQGIVINNLS 277

  Fly   299 AHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPLPSTPS 343
            :...||::|:....:|||.|::.|.||....|:.:..|..|:|.|
Zfish   278 SRSVLTVKNMTQDRYGNYTCVAVNRLGTANASVPLNPIIEPTTTS 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	26/92 (28%)
		Ig	145..238	CDD:416386	30/93 (32%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	3/4 (75%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	1/3 (33%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	1/7 (14%)
		Ig	242..333	CDD:416386	22/100 (22%)
		Ig strand A'	250..253	CDD:409353	0/4 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/11 (9%)
		Ig strand E	295..305	CDD:409353	2/9 (22%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	2/8 (25%)
negr1	XP_009300786.1	Ig	42..121	CDD:299845	21/72 (29%)
		IG_like	44..136	CDD:214653	25/90 (28%)
		I-set	140..222	CDD:254352	30/93 (32%)
		IGc2	153..208	CDD:197706	22/63 (35%)
		IG_like	236..312	CDD:214653	19/87 (22%)
		IGc2	238..304	CDD:197706	16/77 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820