DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and LSAMP

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001305844.1	Gene:	LSAMP / 4045	HGNCID:	6705	Length:	361	Species:	Homo sapiens

Alignment Length:	333	Identity:	100/333 - (30%)
Similarity:	146/333 - (43%)	Gaps:	49/333 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIP------RYSITYT 104
            |.:...|:||..|..|.|.||||.... ||||  ::|..|:.......|..|      |:|:.|:
Human    34 FNRGTDNITVRQGDTAILRCVVEDKNS-KVAW--LNRSGIIFAGHDKWSLDPRVELEKRHSLEYS 95

  Fly   105 DNTWLLHVNQAHQDDRGYYMCQVNT--NPMISQVGYLQVVVPPNILDIESTPSSVAVRENQNINM 167
                 |.:.:....|.|.|.|.|.|  .|..||| ||.|.|||.|.:|.   |.|.|.|..|:.:
Human    96 -----LRIQKVDVYDEGSYTCSVQTQHEPKTSQV-YLIVQVPPKISNIS---SDVTVNEGSNVTL 151

  Fly   168 TCRADGFPAPKIIWR------RE-DGEEIAVEKKKKVLVYDADVLPLTKVSRNEMGAYLCIATNG 225
            .|.|:|.|.|.|.||      || :|||              :.|.:..::|.:.|.|.|.|.|.
Human   152 VCMANGRPEPVITWRHLTPTGREFEGEE--------------EYLEILGITREQSGKYECKAANE 202

  Fly   226 VPPSVSKRIILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYNSVMVLPSKKYKT 290
            |..:..|::.:.|.:.|.| ..::...|.:|...::.|...|.|.....|..:...:..:...:.
Human   203 VSSADVKQVKVTVNYPPTI-TESKSNEATTGRQASLKCEASAVPAPDFEWYRDDTRINSANGLEI 266

  Fly   291 DYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPLPSTPSK-QVTHTTVESR 354
            ..||    ....||:.|:....:|||.|::.|.||.|..|:.:::..||:.|.. |...|||..:
Human   267 KSTE----GQSSLTVTNVTEEHYGNYTCVAANKLGVTNASLVLFKRVLPTIPHPIQEIGTTVHFK 327

  Fly   355 ENNIIPSS 362
            :..  |.|
Human   328 QKG--PGS 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	35/99 (35%)
		Ig	145..238	CDD:416386	30/99 (30%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	2/4 (50%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	3/10 (30%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	1/7 (14%)
		Ig	242..333	CDD:416386	22/90 (24%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	1/9 (11%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	3/8 (38%)
LSAMP	NP_001305844.1	Ig	38..128	CDD:386229	34/98 (35%)
		Ig	132..215	CDD:386229	30/99 (30%)
		Ig_3	219..294	CDD:372822	17/79 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12195
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4481
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		mtm8497
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870