DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and Sdk2

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	341	Identity:	74/341 - (21%)
Similarity:	139/341 - (40%)	Gaps:	56/341 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 MMDEPRFA-QPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITY 103
            :::.|:|. :|..::|..:.:..::||..:.:....:.| :.|..::      .:.::.|:. ..
  Rat   307 VLEPPQFVREPERHITAEMEKVVDIPCRAKGVPPPSITW-YKDAALV------EVGKLTRFK-QR 363

  Fly   104 TDNTWLLHVNQAHQDDRGYYMCQVNTNPMISQVG-YLQVV-VPPNIL--DIESTPSSVAVRENQN 164
            :|..  |.::....||.|...|..:.....:|.. ||.|. :.|||.  .::||     |.:..:
  Rat   364 SDGG--LQISGLLPDDTGMVQCFAHNAAGEAQTSTYLAVTSIAPNITRGPLDST-----VIDGMS 421

  Fly   165 INMTCRADGFPAPKIIWRREDGEEI----AVEKKKKVLVYDADVLPLTKVSRNEMGAYLCIATNG 225
            :.:.|...|.|.|.|.|::  ||.|    :|:..:..|:....:| ::....::.|.|.|:|||
  Rat   422 VVLACETSGAPRPAITWQK--GERILASGSVQLPRFTLLESGSLL-ISPTHISDAGTYTCLATN- 482

  Fly   226 VPPSVSKRIILDVEFSPMIWVPNQLVGAP------SGTDVTIDCHTEAHPKAIIYWVYNSVMVLP 284
                  .|.:.:.....::|...::...|      .||..::.|.....|:..:.:|:
  Rat   483 ------SRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTVRYVW------- 534

  Fly   285 SKKYKTDYTENSYRAHM----KLTIRNLQYGDFGNYRC--ISKNSLGETEGSIRVYEIPLPSTPS 343
            .|...|...|.:.|..:    .|.|.....||.|.|.|  :|..........:||.:  ||..|.
  Rat   535 EKDGATLAVETNPRIRLDRNGSLHISQTWSGDIGTYTCRVLSAGGNDSRNAHLRVRQ--LPHAPE 597

  Fly   344 KQV-THTTVESRENNI 358
            ..| |.:|:|.|..|:
  Rat   598 HPVATLSTMERRAINL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	16/93 (17%)
		Ig	145..238	CDD:416386	25/98 (26%)
		Ig strand A	145..149	CDD:409353	3/5 (60%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	1/7 (14%)
		Ig	242..333	CDD:416386	19/102 (19%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	0/4 (0%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	2/13 (15%)
		Ig strand F	314..322	CDD:409353	4/9 (44%)
		Ig strand G	325..334	CDD:409353	1/8 (13%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653
		IGc2	43..101	CDD:197706
		IG_like	123..206	CDD:214653
		Ig	135..191	CDD:299845
		IG_like	225..307	CDD:214653	74/341 (22%)
		IGc2	236..289	CDD:197706
		I-set	311..400	CDD:254352	18/98 (18%)
		Ig	329..397	CDD:143165	12/77 (16%)
		I-set	405..495	CDD:254352	25/104 (24%)
		Ig	419..495	CDD:299845	19/85 (22%)
		Ig	505..589	CDD:299845	18/90 (20%)
		IG_like	505..589	CDD:214653	18/90 (20%)
		FN3	593..684	CDD:238020	8/21 (38%)
		FN3	696..789	CDD:238020
		FN3	797..893	CDD:238020
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810