DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-delta and LRIT3

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	451	Identity:	81/451 - (17%)
Similarity:	150/451 - (33%)	Gaps:	145/451 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NLVTHVMMDEPRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIP- 97
            |.:|.|..:..|:.:.:..:.::..|...||      ..:..:|.|     :::....|:...|
Human   139 NKITSVPNEALRYLKNLAYLDLSSNRLTTLP------PDFLESWTH-----LVSTPSGVLDLSPS 192

  Fly    98 RYSITYTDNTWL--LHVNQAHQDDRGYYMCQVNTNPMIS------------QVGYLQVVVPPNIL 148
            |..:...||.|.  .|:::..:..:......|..:|:::            |...|:..:.|:::
Human   193 RIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQRAELEHCLKPSVM 257

  Fly   149 DIESTPSSVAVRENQNINMTCRADGFPAPKIIWRREDGEEIAVEKKKKVLVYDADVLPLTKVSRN 213
               ::.:.:......|:.:.|.|.|||.|:|.|.|.|.
Human   258 ---TSATKIMSALGSNVLLRCDATGFPTPQITWTRSDS--------------------------- 292

  Fly   214 EMGAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYN 278
                                       ||:              :.|:   .:..|:..:.|...
Human   293 ---------------------------SPV--------------NYTV---IQESPEEGVRWSIM 313

  Fly   279 SVMVLPSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPLPSTP- 342
            |:..:.||                         |.|:|:|.:||..|.:|..:.|..:.:.:||
Human   314 SLTGISSK-------------------------DAGDYKCKAKNLAGMSEAVVTVTVLGITTTPI 353

  Fly   343 SKQVTHTTVESRENNIIPSSRNDTTKSLQTDVGYAMKNDLYPGS------------ASSSSSGGS 395
            ....:..|.:..|.::.|.|...|  |:.:...|...:...|.|            ||.|.|..|
Human   354 PPDTSERTGDHPEWDVQPGSGRST--SVSSASSYLWSSSFSPTSSFSASTLSPPSTASFSLSPFS 416

  Fly   396 SSAASSSSSMQTSALPGGVAGNSLS---SMGSKGSLAIGKSTFYTERPPNEYAASSVAGLL 453
            ||..||::::.||........|..|   ..|.|.:|.:.|:.  ::.||...:......||
Human   417 SSTVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNG--SKLPPASTSKKEELALL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	16/106 (15%)
		Ig	145..238	CDD:416386	12/92 (13%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	1/1 (100%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	0/5 (0%)
		Ig strand F	216..223	CDD:409353	0/6 (0%)
		Ig strand G	230..238	CDD:409353	0/7 (0%)
		Ig	242..333	CDD:416386	15/90 (17%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	0/9 (0%)
		Ig strand F	314..322	CDD:409353	3/7 (43%)
		Ig strand G	325..334	CDD:409353	2/8 (25%)
LRIT3	NP_940908.3	LRR 1	56..79
		leucine-rich repeat	59..82	CDD:275378
		LRR_8	61..117	CDD:290566
		LRR 2	80..103
		leucine-rich repeat	83..106	CDD:275378
		LRR 3	104..128
		LRR_8	105..165	CDD:290566	4/25 (16%)
		LRR_4	105..146	CDD:289563	3/6 (50%)
		leucine-rich repeat	107..130	CDD:275378
		LRR 4	129..151		3/11 (27%)
		LRR_4	131..170	CDD:289563	7/36 (19%)
		leucine-rich repeat	131..154	CDD:275378	4/14 (29%)
		LRR 5	152..175		3/28 (11%)
		leucine-rich repeat	155..168	CDD:275378	1/12 (8%)
		Ig	267..345	CDD:299845	28/173 (16%)
		IG_like	267..345	CDD:214653	28/173 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		6/23 (26%)
		FN3	486..550	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900