DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and DIP-iota

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	320	Identity:	134/320 - (41%)
Similarity:	200/320 - (62%)	Gaps:	9/320 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 EPRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITYTDN- 106
            :|:|:.||.|.||.|||||.|.|||..|..:||||:.:|.|.||:|..|||::..|.||::|::
  Fly    30 DPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNHVITKNHRISISHTEHR 94

  Fly   107 TWLLHVNQAHQDDRGYYMCQVNTNPMISQVGYLQVVVPPNILDIESTPSSVAVRENQNINMTCRA 171
            .|.|.:....:.|||:||||:||:||.||:|||.|||||:|:|.: |...|.....||:.:||.|
  Fly    95 IWQLKIRDVQESDRGWYMCQINTDPMKSQMGYLDVVVPPDIVDYQ-TSQDVVRSTGQNVTLTCSA 158

  Fly   172 DGFPAPKIIWRREDGEEIAV--EKKKKVLVYDADVLPLTKVSRNEMGAYLCIATNGVPPSVSKRI 234
            .|.|.|.|.||||:...|.:  :..::|...:...|.|.:|.|:.||||||||:|||||:||||:
  Fly   159 TGVPMPTITWRREEATPILISDDGDREVFSVEGQNLTLWQVQRSHMGAYLCIASNGVPPTVSKRV 223

  Fly   235 ILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYNSVMVLPSKKYKTDYTENSYRA 299
            :|.|.|:|.||.....:....|..:|::|.||:.|.::.:|:.:| .:|....|::...::.:|.
  Fly   224 MLVVNFAPTIWTRYDTIYVGLGQKLTLECITESQPASVNFWLRDS-QLLQGGSYESVSVDHVFRI 287

  Fly   300 HMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPLPSTPSKQVTHTTVESRENNII 359
            .|::|:|.:...|||.|.|.:||::|:|:..|.|:.   .:....|.:|.| .|||:..|
  Fly   288 VMRITLRPITKRDFGEYICRAKNAMGQTDRIITVHH---KAKKHGQHSHQT-SSRESQFI 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	48/92 (52%)
		Ig	145..238	CDD:416386	42/94 (45%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	165..172	CDD:409353	2/6 (33%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	1/3 (33%)
		Ig strand E	203..209	CDD:409353	2/5 (40%)
		Ig strand F	216..223	CDD:409353	6/6 (100%)
		Ig strand G	230..238	CDD:409353	5/7 (71%)
		Ig	242..333	CDD:416386	27/90 (30%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	2/9 (22%)
		Ig strand F	314..322	CDD:409353	3/7 (43%)
		Ig strand G	325..334	CDD:409353	3/8 (38%)
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	44/85 (52%)
		Ig	39..122	CDD:299845	42/82 (51%)
		Ig	132..213	CDD:299845	33/81 (41%)
		IG_like	141..227	CDD:214653	38/85 (45%)
		IG_like	239..322	CDD:214653	24/83 (29%)
		IGc2	245..313	CDD:197706	21/68 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12510
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4644
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102261at50557
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	1	1.000	-	-		otm26286
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	8	7.870