DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and sdk

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001284756.1	Gene:	sdk / 31017	FlyBaseID:	FBgn0021764	Length:	2265	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	100/453 - (22%)
Similarity:	157/453 - (34%)	Gaps:	119/453 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 NVTVAVGRD-ANLPCV--VEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITYTDNTW----- 108
            :|.|.||.. ..|.|:  ...|...:..|:.....:.....||.:           ::.|
  Fly   269 DVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTL-----------NDPWNRTLA 322

  Fly   109 LLHVNQAHQDDRGYYMCQVNTN----PMISQVGYLQVVVPPNILDIESTPSSVAV--RENQNINM 167
            ||..|.:|.   |.|.|||...    |.:|....||::.||    :..||.....  .....:.:
  Fly   323 LLQANSSHS---GEYTCQVRLRSGGYPAVSASARLQILEPP----LFFTPMRAETFGEFGGQVQL 380

  Fly   168 TCRADGFPAPKIIW-RREDGEEIAVEKK------------KKVLVYDA---DVLPLTKVSRNEMG 216
            ||...|.|.|::.| |..:..:..:|..            ||:::.||   ..|.:.:...|...
  Fly   381 TCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSAS 445

  Fly   217 AYLCIATNGVPPSVSKRI----ILDV----------------------EF----SPMIWVPNQLV 251
            .:|.:.|......| ||:    ||.|                      ||    :|::.:|.|.|
  Fly   446 TWLRVKTKTAKNRV-KRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNV 509

  Fly   252 GAPSGTDVTIDCHTEAHPKAIIYWVYNSVMVLPSKKYKTDYTENSYRAHM----KLTIRNLQYGD 312
            .|..|.|.||.|.....|...|.|:||          :|...:.|.|..:    .|.|.|::..|
  Fly   510 TALDGKDATISCRAVGSPNPNITWIYN----------ETQLVDISSRVQILESGDLLISNIRSVD 564

  Fly   313 FGNYRCISKNSLGETEGS--------IRVYEIPLPSTPSKQVTHT---TVES-----------RE 355
            .|.|.|:..|..|..:|.        .::.:.|:.:|....:|.|   .|.|           ||
  Fly   565 AGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYRE 629

  Fly   356 NN----IIPSSRNDTTKSLQTDVGYAMKNDLYPGSASSSSSGGSSSAASSSSSMQTSALPGGV 414
            ..    |..|.|.......|.::.....:|:...:...:|.||:.:.|:..|.::....|..|
  Fly   630 GQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNV 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	24/102 (24%)
		Ig	145..238	CDD:416386	24/114 (21%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	165..172	CDD:409353	2/6 (33%)
		Ig strand C	178..183	CDD:409353	1/5 (20%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	2/3 (67%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	1/6 (17%)
		Ig strand G	230..238	CDD:409353	5/11 (45%)
		Ig	242..333	CDD:416386	28/102 (27%)
		Ig strand A'	250..253	CDD:409353	1/2 (50%)
		Ig strand B	259..266	CDD:409353	3/6 (50%)
		Ig strand C	272..277	CDD:409353	2/4 (50%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	3/13 (23%)
		Ig strand F	314..322	CDD:409353	3/7 (43%)
		Ig strand G	325..334	CDD:409353	2/16 (13%)
sdk	NP_001284756.1	Ig	71..157	CDD:299845
		I-set	72..150	CDD:254352
		Ig	172..245	CDD:299845
		IG_like	280..356	CDD:214653	19/89 (21%)
		Ig	280..343	CDD:299845	16/76 (21%)
		IG_like	375..450	CDD:214653	15/74 (20%)
		Ig	378..447	CDD:143165	14/68 (21%)
		Ig	506..587	CDD:299845	26/90 (29%)
		IG_like	506..587	CDD:214653	26/90 (29%)
		I-set	592..682	CDD:254352	17/89 (19%)
		Ig	595..682	CDD:299845	17/86 (20%)
		FN3	686..789	CDD:238020	2/7 (29%)
		FN3	798..893	CDD:238020
		FN3	901..1005	CDD:238020
		fn3	1011..1094	CDD:278470
		FN3	1108..1202	CDD:238020
		FN3	1210..1308	CDD:238020
		fn3	1317..1402	CDD:278470
		FN3	1415..1507	CDD:238020
		FN3	1513..1608	CDD:238020
		fn3	1617..1708	CDD:278470
		FN3	1722..1823	CDD:238020
		FN3	1828..1920	CDD:238020
		FN3	1927..2016	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810