DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and PRTG

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_776175.2	Gene:	PRTG / 283659	HGNCID:	26373	Length:	1150	Species:	Homo sapiens

Alignment Length:	412	Identity:	91/412 - (22%)
Similarity:	141/412 - (34%)	Gaps:	114/412 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 QPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITYTDNTWLLHV 112
            ||| :..|..|..|...|.:.......:.|......:.:|:.|  |:.:|         |.:|.:
Human   140 QPI-STEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDR--ITALP---------TGVLQI 192

  Fly   113 NQAHQDDRGYYMCQVNTNPMISQVGYLQ-------VVVPPNILDIESTPSSVAVREN------QN 164
            ....|.|.|.|.|      :.:.|.:.:       .|:|........||:.:|..:|      |.
Human   193 YDVSQRDSGNYRC------IAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQT 251

  Fly   165 INMTCRADGFPAPKIIWRREDGEEIAVEKKKKVLVYDADVLPLTKVSRNEMGAYLCIATNG---- 225
            :.:.|.|.|.|.|.|.|.|.|.:.|.|...:   |.....|.::.|.....|.|:|.||..
Human   252 VVLECMATGNPKPIISWSRLDHKSIDVFNTR---VLGNGNLMISDVRLQHAGVYVCRATTPGTRN 313

  Fly   226 -----------VPPSVSKRIILDVEFSPMIWVPNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYNS 279
                       .|||.       ||     | |..|....:|| ....|..|..|...:.|:.|
Human   314 FTVAMATLTVLAPPSF-------VE-----W-PESLTRPRAGT-ARFVCQAEGIPSPKMSWLKN- 363

  Fly   280 VMVLPSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLG------------------- 325
                 .:|..::.....|.:  ||.|..:...|...|:|:::||.|
Human   364 -----GRKIHSNGRIKMYNS--KLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSA 421

  Fly   326 ------ETEGS---IRVYEIPLPSTPSKQVTHTT-------VESRENNIIPSSRNDTTKSLQTDV 374
                  ||..|   :..:|.||.:: .|.:.::.       :.:.|..::..  ||||..:..|:
Human   422 PYNVHAETMSSSAILLAWERPLYNS-DKVIAYSVHYMKAEGLNNEEYQVVIG--NDTTHYIIDDL 483

  Fly   375 GYAMKNDLY-----PGSASSSS 391
            ..|.....|     |..||..|
Human   484 EPASNYTFYIVAYMPMGASQMS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	17/98 (17%)
		Ig	145..238	CDD:416386	27/113 (24%)
		Ig strand A	145..149	CDD:409353	0/3 (0%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	1/1 (100%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	0/7 (0%)
		Ig	242..333	CDD:416386	24/118 (20%)
		Ig strand A'	250..253	CDD:409353	1/2 (50%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	3/9 (33%)
		Ig strand F	314..322	CDD:409353	2/7 (29%)
		Ig strand G	325..334	CDD:409353	4/36 (11%)
PRTG	NP_776175.2	Ig	40..130	CDD:299845
		Ig	139..223	CDD:299845	20/100 (20%)
		IG_like	141..223	CDD:214653	19/99 (19%)
		IG_like	241..323	CDD:214653	21/84 (25%)
		IGc2	250..309	CDD:197706	20/61 (33%)
		I-set	327..412	CDD:254352	25/106 (24%)
		Ig	345..412	CDD:299845	16/74 (22%)
		FN3	419..512	CDD:238020	19/90 (21%)
		FN3	517..610	CDD:238020
		fn3	624..699	CDD:278470
		FN3	726..814	CDD:238020
		FN3	821..911	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1086..1150
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100