DRSC/TRiP Functional Genomics Resources

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Protein Alignment DIP-delta and LRIT1

DIOPT Version :9

Sequence 1:NP_001097508.2 Gene:DIP-delta / 5740816 FlyBaseID:FBgn0085420 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_056428.1 Gene:LRIT1 / 26103 HGNCID:23404 Length:623 Species:Homo sapiens


Alignment Length:356 Identity:71/356 - (19%)
Similarity:126/356 - (35%) Gaps:98/356 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 RIMFLIYMTNLVTHVMMDEPRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIH 89
            ::..|....|.::.|..:..||.:.:..:.::..:...||   :.|   .|:|.|::..:....|
Human   132 KLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLMRLP---QEL---IVSWAHLETGIFPPGH 190

  Fly    90 RHVISRIPRYSITYTDNTW--------LLHVNQAHQDDRGYYMCQVN-TNP-MISQVGYLQV--- 141
            .      ||..:...||.|        |:|:......:..:...::. .:| .::.|.:.|:   
Human   191 H------PRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELR 249

  Fly   142 -----VVPPNILDIESTPSSVAVRENQNINMTCRADGFPAPKIIWRREDGEEIAVEKKKKVLVYD 201
                 .:.|.:..|.|.....|:       :.|.|.|.|.|::.|||.:|..:.....::|   .
Human   250 KCQGPELHPGVASIRSLLGGTAL-------LRCGATGVPGPEMSWRRANGRPLNGTVHQEV---S 304

  Fly   202 AD-----VLPLTKVSRNEMGAYLCIATN--GVPPSVSKRIILDVEFSP-------MIWV------ 246
            :|     :|.|..||..:.|.|:|.|.|  |...:|...|:.:...|.       .:|.      
Human   305 SDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGGGG 369

  Fly   247 -----PNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYNSVMVLPSKKYKTDYTENSYRAHMKLTIR 306
                 .|:||..          |....||..:.....||   ||.|             .:||:.
Human   370 EAAAYNNKLVAR----------HVPQIPKPAVLATGPSV---PSTK-------------EELTLE 408

  Fly   307 NLQYGDFGNYRCISKNSLGETEG----SIRV 333
            :.|....|.   :|....|.:|.    |::|
Human   409 HFQMDALGE---LSDGRAGPSEARMVRSVKV 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-deltaNP_001097508.2 IG 51..143 CDD:214652 17/109 (16%)
Ig 145..238 CDD:416386 27/99 (27%)
Ig strand A 145..149 CDD:409353 1/3 (33%)
Ig strand A' 154..159 CDD:409353 0/4 (0%)
Ig strand B 165..172 CDD:409353 1/6 (17%)
Ig strand C 178..183 CDD:409353 1/4 (25%)
Ig strand C' 185..187 CDD:409353 0/1 (0%)
Ig strand D 195..199 CDD:409353 1/3 (33%)
Ig strand E 203..209 CDD:409353 3/10 (30%)
Ig strand F 216..223 CDD:409353 3/6 (50%)
Ig strand G 230..238 CDD:409353 2/7 (29%)
Ig 242..333 CDD:416386 20/112 (18%)
Ig strand A' 250..253 CDD:409353 2/2 (100%)
Ig strand B 259..266 CDD:409353 1/6 (17%)
Ig strand C 272..277 CDD:409353 0/4 (0%)
Ig strand C' 281..283 CDD:409353 0/1 (0%)
Ig strand D 289..293 CDD:409353 0/3 (0%)
Ig strand E 295..305 CDD:409353 1/9 (11%)
Ig strand F 314..322 CDD:409353 2/7 (29%)
Ig strand G 325..334 CDD:409353 4/13 (31%)
LRIT1NP_056428.1 LRR 1 60..81
leucine-rich repeat 61..84 CDD:275378
LRR_8 63..143 CDD:290566 2/10 (20%)
LRR 2 84..105
leucine-rich repeat 85..132 CDD:275378 71/356 (20%)
LRR 3 108..129
LRR_8 131..202 CDD:290566 15/81 (19%)
LRR_4 131..171 CDD:289563 5/38 (13%)
LRR 4 132..153 3/20 (15%)
leucine-rich repeat 133..156 CDD:275378 5/22 (23%)
LRR 5 156..177 3/26 (12%)
leucine-rich repeat 157..180 CDD:275378 5/28 (18%)
leucine-rich repeat 181..205 CDD:275378 6/29 (21%)
TPKR_C2 201..>240 CDD:301599 5/38 (13%)
Ig 267..345 CDD:299845 23/87 (26%)
IG_like 267..345 CDD:214653 23/87 (26%)
FN3 431..498 CDD:214495 2/6 (33%)
LRR 6. /evidence=ECO:0000305 571..594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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