DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and Ncam1

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_038936733.1	Gene:	Ncam1 / 24586	RGDID:	67378	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	115/497 - (23%)
Similarity:	183/497 - (36%)	Gaps:	123/497 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITYTDNTWLLHVNQAHQDDRGY 122
            |.||.:.|.|.......:.|.|..|.:||       .:..|: |..::|  .|.:....:.|.|.
  Rat   132 GEDAVIVCDVVSSLPPTIIWKHKGRDVIL-------KKDVRF-IVLSNN--YLQIRGIKKTDEGT 186

  Fly   123 YMC--------QVNTNPMISQVGYLQVV--VPPNILDIESTPSSVAVRENQNINMTCRADGFPAP 177
            |.|        ::|...       :||:  |||.:...:|..::.| ...|::.:.|.|||||.|
  Rat   187 YRCEGRILARGEINFKD-------IQVIVNVPPTVQARQSIVNATA-NLGQSVTLVCDADGFPEP 243

  Fly   178 KIIWRREDGEEIAVEK---KKKVLVYDADVLPLTKVSRNEMGAYLCIATNGVPPSVSKRIILDVE 239
            .:.|.: |||.|..|:   :|.:...|:..|.:..|.:|:...|:|||.|..... ...|.|.|.
  Rat   244 TMSWTK-DGEPIENEEEDDEKHIFSDDSSELTIRNVDKNDEAEYVCIAENKAGEQ-DASIHLKVF 306

  Fly   240 FSPMI-WVPNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYNSVMVLPSKKYKTDYT----ENSYRA 299
            ..|.| :|.|| ........||:.|.....|...|.|..::..:  |.:.|..:|    :.:...
  Rat   307 AKPKITYVENQ-TAMELEEQVTLTCEASGDPIPSITWRTSTRNI--SSEEKASWTRPEKQETLDG 368

  Fly   300 HM---------KLTIRNLQYGDFGNYRCISKNSLGE--------------TEGSIRVYEIPLPST 341
            ||         .||::::||.|.|.|.|.:.|::|:              .:|.:.||     :.
  Rat   369 HMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVY-----TW 428

  Fly   342 PSKQVTHT---------TVE-SRENNIIPSSRNDTTKSLQT------DVGYAMKND--------- 381
            ...||..|         |:. .|:..::|||.....|...|      :|....:||
  Rat   429 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAV 493

  Fly   382 -----------LYPGSASSSSSGGSSSAASSSSSMQTSALPGGVAGNSL-------SSMGSKGSL 428
                       |......||.|.......||::.:|... |....|..:       .|:|.:.
  Rat   494 NRIGQESLEFILVQADTPSSPSIDRVEPYSSTAQVQFDE-PEATGGVPILKYKAEWKSLGEEA-- 555

  Fly   429 AIGKSTFYTERPPNEYAASSVAGL------LLHRALLFGSGI 464
              ..|.:|..:..|.....::.||      .:..|.|.|.|:
  Rat   556 --WHSKWYDAKEANMEGIVTIMGLKPETRYAVRLAALNGKGL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	21/94 (22%)
		Ig	145..238	CDD:416386	29/95 (31%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	0/4 (0%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	1/4 (25%)
		Ig strand C'	185..187	CDD:409353	1/1 (100%)
		Ig strand D	195..199	CDD:409353	1/3 (33%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	2/7 (29%)
		Ig	242..333	CDD:416386	27/118 (23%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	3/6 (50%)
		Ig strand C	272..277	CDD:409353	2/4 (50%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	3/18 (17%)
		Ig strand F	314..322	CDD:409353	3/7 (43%)
		Ig strand G	325..334	CDD:409353	2/22 (9%)
Ncam1	XP_038936733.1	IgI_1_NCAM-1	20..116	CDD:409451
		Ig strand B	37..41	CDD:409451
		Ig strand C	51..55	CDD:409451
		Ig strand E	79..83	CDD:409451
		Ig strand F	93..98	CDD:409451
		Ig strand G	107..110	CDD:409451
		IG_like	124..190	CDD:214653	17/67 (25%)
		Ig strand B	135..139	CDD:409353	1/3 (33%)
		Ig strand C	148..152	CDD:409353	0/3 (0%)
		Ig strand E	172..176	CDD:409353	2/5 (40%)
		Ig strand F	186..191	CDD:409353	2/4 (50%)
		IgI_3_NCAM-1	211..308	CDD:143207	31/99 (31%)
		Ig strand B	231..235	CDD:143207	0/3 (0%)
		Ig strand C	244..248	CDD:143207	0/3 (0%)
		Ig strand E	271..275	CDD:143207	1/3 (33%)
		Ig strand F	285..290	CDD:143207	2/4 (50%)
		Ig strand G	298..301	CDD:143207	0/2 (0%)
		IgI_NCAM-1	307..413	CDD:143277	26/108 (24%)
		Ig strand B	326..330	CDD:143277	2/3 (67%)
		Ig strand C	339..343	CDD:143277	1/3 (33%)
		Ig strand E	379..383	CDD:143277	1/3 (33%)
		Ig strand F	393..398	CDD:143277	2/4 (50%)
		Ig strand G	406..409	CDD:143277	0/2 (0%)
		Ig_3	422..494	CDD:404760	15/76 (20%)
		Ig strand B	433..437	CDD:409353	1/3 (33%)
		Ig strand C	446..450	CDD:409353	1/3 (33%)
		Ig strand E	473..477	CDD:409353	0/3 (0%)
		Ig strand F	487..492	CDD:409353	0/4 (0%)
		FN3	509..606	CDD:238020	19/92 (21%)
		fn3	619..701	CDD:394996
		Herpes_BLLF1	<842..1133	CDD:282904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910