DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DIP-delta and SDK1

DIOPT Version :9

Sequence 1:NP_001097508.2 Gene:DIP-delta / 5740816 FlyBaseID:FBgn0085420 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:502 Identity:104/502 - (20%)
Similarity:167/502 - (33%) Gaps:111/502 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 PSRFTNRRIMFLIYMTNLVTHVMMDEPRF-AQPIPNVTVAVGRDANLPC-----VVEHLGGYKVA 76
            |:|.|  ..:|:|           :.|.| |:|...::..|....::.|     .:..|..||.|
Human   373 PARAT--AFLFII-----------EPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDA 424

  Fly    77 WIHIDRQMILTIHRHVISRIPRYSITYTDNTWLLHVNQAHQDDRGYYMC-QVNTNPMISQVGYLQ 140
             |.|.|           .:.|||.:..:..   |.:.:...:|.|.:.| ..|....|....||.
Human   425 -ISISR-----------LQNPRYKVLASGG---LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLD 474

  Fly   141 VVVPPNILDI-ESTPSSVAVRENQNINMTCRADGFPAPKIIWRREDGEEIAVEKKKKV---LVYD 201
            |.   ||..: ...|....|.:.....:.|...|.|.|.|.|:||:  .|......::   ::.:
Human   475 VT---NIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKREN--HILASGSVRIPRFMLLE 534

  Fly   202 ADVLPLTKVSRNEMGAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQLVGAP------SGTDVT 260
            :..|.:..|...:.|.|.|.|.| ...|::....|.|      |....:|..|      .||..|
Human   535 SGGLQIAPVFIQDAGNYTCYAAN-TEGSLNASATLTV------WNRTSIVHPPEDHVVIKGTTAT 592

  Fly   261 IDCHTEAHPKAII--YWVYNSVMVLPSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNS 323
            :.|.....|:..:  .|..::|.:.||...:....::.     .|.|.....||.|:|.|...:.
Human   593 LHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDG-----SLLISQTWSGDIGDYSCEIVSE 652

  Fly   324 LGETEGSIRVYEIPLPSTP-------------------------SKQVTHTTVESREN------- 356
            .|......|:..|.||.:|                         :..:.:..||..||       
Human   653 GGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVH 717

  Fly   357 --NIIPSSRNDTTKSLQTDVGYAMKNDLYPGSASSSSSGGSSSAASSSSSMQTSALPGGVAGNSL 419
              |:.|.....|...|.....|..:      ..:.:..|....:|.:|..|.....|.....|.:
Human   718 LSNVGPEMTGVTVSGLTPARTYQFR------VCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIV 776

  Fly   420 SSMGSKGSLAIGKSTFYTERPPNEYAASSV-AGLLLHRALLFGSGIY 465
            :|..:..|:.:      ..:||.|...:.| .|.:|...|....|.|
Human   777 ASGRTNQSIMV------QWQPPPETEHNGVLRGYILRYRLAGLPGEY 817

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DIP-deltaNP_001097508.2 IG 51..143 CDD:214652 21/97 (22%)
Ig 145..238 CDD:416386 22/96 (23%)
Ig strand A 145..149 CDD:409353 2/3 (67%)
Ig strand A' 154..159 CDD:409353 1/4 (25%)
Ig strand B 165..172 CDD:409353 1/6 (17%)
Ig strand C 178..183 CDD:409353 2/4 (50%)
Ig strand C' 185..187 CDD:409353 0/1 (0%)
Ig strand D 195..199 CDD:409353 0/6 (0%)
Ig strand E 203..209 CDD:409353 1/5 (20%)
Ig strand F 216..223 CDD:409353 3/6 (50%)
Ig strand G 230..238 CDD:409353 1/7 (14%)
Ig 242..333 CDD:416386 20/98 (20%)
Ig strand A' 250..253 CDD:409353 1/2 (50%)
Ig strand B 259..266 CDD:409353 2/6 (33%)
Ig strand C 272..277 CDD:409353 1/6 (17%)
Ig strand C' 281..283 CDD:409353 0/1 (0%)
Ig strand D 289..293 CDD:409353 0/3 (0%)
Ig strand E 295..305 CDD:409353 1/9 (11%)
Ig strand F 314..322 CDD:409353 3/7 (43%)
Ig strand G 325..334 CDD:409353 2/8 (25%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845
IGc2 312..364 CDD:197706
I-set 386..475 CDD:254352 24/103 (23%)
Ig 404..472 CDD:143165 17/82 (21%)
I-set 480..570 CDD:254352 20/92 (22%)
Ig 494..570 CDD:299845 18/78 (23%)
I-set 575..664 CDD:254352 20/93 (22%)
Ig 580..664 CDD:299845 19/88 (22%)
FN3 668..759 CDD:238020 13/96 (14%)
fn3 771..857 CDD:278470 12/53 (23%)
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.