DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and Ncam2

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	454	Identity:	105/454 - (23%)
Similarity:	175/454 - (38%)	Gaps:	84/454 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LIYMTNLVTHVMMDEPRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVI 93
            :|.:.|:...:||.:..|     |.|...|.:..|.|.........::|..         :..:|
Mouse   201 IIVIVNVPPAIMMPQKSF-----NATAERGEEMTLTCKASGSPDPTISWFR---------NGKLI 251

  Fly    94 SRIPRYSITYTDNTWLLHVNQAHQDDRGYYMCQVNTNPMISQ-VGYLQVVVPPNILDIESTPSSV 157
            ....:| |....||.|. |......|.|.|:|:........| ..:|||.|.|:||.:::..:|
Mouse   252 EENEKY-ILKGSNTELT-VRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNETTS- 313

  Fly   158 AVRENQNINMTCRADGFPAPKIIWRR-------EDGEEI---AVEKKKKVLVYDADVLPLTKVSR 212
               ||.::.:.|.|:|.|.|:|.|:|       .:|::.   .:|.|.:   :....|.:..|..
Mouse   314 ---ENGHVTLVCEAEGEPVPEITWKRAIDGVMFSEGDKSPDGRIEVKGQ---HGRSSLHIRDVKL 372

  Fly   213 NEMGAYLCIATNGVPPSVSKRIILDVEFSPMIWVPNQ-LVGAPSGTDVTIDCHTEAHPKAIIYWV 276
            ::.|.|.|.|.:.: ....:.:.||:|::|. :|.|| :..:..|..:.|.|...|:|.|.|:|
Mouse   373 SDSGRYDCEAASRI-GGHQRSMHLDIEYAPK-FVSNQTMYYSWEGNPINISCDVTANPPASIHW- 434

  Fly   277 YNSVMVLPSKKYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPLPST 341
            ....::||:|. .|....:|....|.|.|......|||.|.|.:.|.:|.   ..:.|.:.|...
Mouse   435 RREKLLLPAKN-TTHLKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIGT---RFQEYILELADV 495

  Fly   342 PSK-------QVTHTTVESRENNIIPSSRNDT-TKSLQTDVGYAMKNDLYPGSASSSSSGGSSSA 398
            ||.       :::.||.:...|.  |.|.... ....|.||                     ...
Mouse   496 PSSPHGVKIIELSQTTAKISFNK--PESHGGVPIHHYQVDV---------------------KEV 537

  Fly   399 ASS------SSSMQTSALPGGVAGNS-----LSSMGSKGSLAIGKSTFYTERPPNEYAASSVAG 451
            ||.      |..:||..:...:..|:     ::::..||.....|...:...|..|.:..|:.|
Mouse   538 ASETWKIVRSHGVQTMVVLSSLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPPSIHG 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	21/92 (23%)
		Ig	145..238	CDD:416386	24/102 (24%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	165..172	CDD:409353	1/6 (17%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	1/7 (14%)
		Ig	242..333	CDD:416386	27/91 (30%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	2/4 (50%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	3/9 (33%)
		Ig strand F	314..322	CDD:409353	3/7 (43%)
		Ig strand G	325..334	CDD:409353	1/8 (13%)
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274
		I-set	22..111	CDD:254352
		I-set	117..193	CDD:254352
		IGc2	128..189	CDD:197706
		Ig	208..301	CDD:299845	24/108 (22%)
		I-set	215..298	CDD:254352	20/98 (20%)
		Ig	300..397	CDD:299845	25/104 (24%)
		IG_like	308..395	CDD:214653	20/94 (21%)
		IG_like	413..491	CDD:214653	24/82 (29%)
		IGc2	414..482	CDD:197706	22/69 (32%)
		FN3	496..588	CDD:238020	19/114 (17%)
		fn3	594..678	CDD:278470	2/8 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000