DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and rig-4

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_501339.2	Gene:	rig-4 / 177597	WormBaseID:	WBGene00004371	Length:	2325	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	114/543 - (20%)
Similarity:	175/543 - (32%)	Gaps:	179/543 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YMTNLVTHVMMDEPRFAQPIPN-VTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVIS 94
            |||.:...::.|       :|| :...||...:|.|.|:......:.|.
Worm   317 YMTFISRPILKD-------LPNEIQKTVGSSLSLKCSVKKKSSMDIKWY---------------- 358

  Fly    95 RIPRYSITYTDNTWLLHVNQAHQDDRGYYMCQVNTNPMISQVGYLQV------------------ 141
               :..:..|.....|.:::..|||.|.|.|:. ||...:.:..:.|
Worm   359 ---KNGLMMTTQRGKLTIDRIKQDDFGLYQCEA-TNAAGADLASVWVKEGEANETVATEMSEDGM 419

  Fly   142 ---------VVPPNIL-----------------DIE------STPSSVAVRE-NQNINMTCRADG 173
                     ..||..|                 ::|      .||..:.|.. ...|.|.|.|.|
Worm   420 SLEEEISMETPPPRKLKFFDNSKSQEQLFPFTSELEPSQKLIKTPKDLTVASGTDRIMMECAATG 484

  Fly   174 FPAPKIIWRREDGEEIAVEKKKKVLVYDA--DVLPLTKVSRNEMGAYLC-IATNGVPPSVSKRII 235
            .|.|.|||.. :|.||..:..|    ||.  |.|.:..:.:::.|.|.| |:.:.|..:.:.::.
Worm   485 SPPPNIIWLL-NGHEIQTDNVK----YDLTNDGLAIHDIRKSDEGEYTCEISGSNVKATANVQVN 544

  Fly   236 LD--VEFSPMIWVPNQLVGAPSGTDVTIDCHT--EAHPKAIIYWVYNSVMVLP---------SKK 287
            .|  :|:.|.  ....|:    ||:|...|..  |...||.:.|..|.|: ||         |:.
Worm   545 GDSLIEYGPA--DQKSLI----GTNVEFSCEVAKEYVRKASVEWYLNDVL-LPVNGNSGLRISRN 602

  Fly   288 YKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPLPSTPSK-------Q 345
            .|.           .|.||.:...:.|.|||.......|...|..:..|..|:.|.:       :
Worm   603 RKG-----------SLIIRQVGPDNTGEYRCRVTVDGREENASAMLQIIEKPAMPERVRAELHNE 656

  Fly   346 VTHTTVESRENNIIPSSR------------------NDTTKSLQ------------TDVGYAMKN 380
            .....|..|.|.....:.                  :|.|.::.            ||:     .
Worm   657 TMPAKVRVRWNEGFDGNEPIIKHAIEMRTMGPTGLWSDWTTAIDNIPKEEGKPCCWTDI-----E 716

  Fly   381 DLYPGS-------ASSSSSGGSSSAASSSSSM---QTSALPGGVAGNSLSSMGSKGSLAIGKSTF 435
            ||.|.|       ||:....|..|..|.|.:|   ..||.|..||    :|..|..|:.:
Worm   717 DLRPSSTAEFRVVASNKHGPGKPSLPSYSVTMPQQPPSAAPRNVA----ASARSPHSVMV----- 772

  Fly   436 YTERPPNEYAASSVAGLLLHRAL 458
            ..::|..|..:..|.|.::...|
Worm   773 QWQQPKEELDSGDVLGYVVRYRL 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	19/119 (16%)
		Ig	145..238	CDD:416386	30/121 (25%)
		Ig strand A	145..149	CDD:409353	2/20 (10%)
		Ig strand A'	154..159	CDD:409353	1/4 (25%)
		Ig strand B	165..172	CDD:409353	3/6 (50%)
		Ig strand C	178..183	CDD:409353	3/4 (75%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	1/3 (33%)
		Ig strand E	203..209	CDD:409353	2/5 (40%)
		Ig strand F	216..223	CDD:409353	4/7 (57%)
		Ig strand G	230..238	CDD:409353	1/9 (11%)
		Ig	242..333	CDD:416386	25/101 (25%)
		Ig strand A'	250..253	CDD:409353	1/2 (50%)
		Ig strand B	259..266	CDD:409353	2/8 (25%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/3 (33%)
		Ig strand E	295..305	CDD:409353	1/9 (11%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	2/8 (25%)
rig-4	NP_501339.2	IG_like	330..402	CDD:214653	18/91 (20%)
		IGc2	338..393	CDD:197706	15/74 (20%)
		I-set	459..543	CDD:254352	26/88 (30%)
		IGc2	478..534	CDD:197706	21/60 (35%)
		IG_like	553..639	CDD:214653	25/103 (24%)
		Ig	564..635	CDD:143165	20/82 (24%)
		FN3	643..747	CDD:238020	19/108 (18%)
		FN3	756..850	CDD:238020	11/49 (22%)
		FN3	858..954	CDD:238020
		FN3	959..1042	CDD:238020
		FN3	1057..1151	CDD:238020
		FN3	1156..1251	CDD:238020
		FN3	1258..1356	CDD:238020
		FN3	1361..1453	CDD:238020
		FN3	1464..1560	CDD:238020
		FN3	1572..1664	CDD:238020
		FN3	1679..1764	CDD:238020
		FN3	1774..1858	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900