DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and Dscaml1

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001074739.2	Gene:	Dscaml1 / 114873	MGIID:	2150309	Length:	2053	Species:	Mus musculus

Alignment Length:	588	Identity:	122/588 - (20%)
Similarity:	191/588 - (32%)	Gaps:	185/588 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHRHVISRIPRYSITYTDNTW 108
            |...:.:.|:|...|||..:.|.|.....|.:.| :.|..::...||.|:         :.:.|.
Mouse   505 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKW-YKDALLLPDNHRQVV---------FENGTL 559

  Fly   109 LLHVNQAHQDDRGYYMCQVNTNPM--ISQVGYLQVVVPPNILDIESTP----------------- 154
            .|...|...|: |.|:|.|...|.  |||..::.|.|||.|...|..|
Mouse   560 KLTDVQKGMDE-GEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGD 623

  Fly   155 ---------------------------------SSVAVRENQNIN-------------------- 166
                                             |||:::.|.|..
Mouse   624 MPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV 688

  Fly   167 --------------------MTCRADGFPAPKIIWRREDGEEIAVEKKKKVLVYDADVLP----- 206
                                :.|..||:|.||::|:...|.....:.....|.....:||
Mouse   689 PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLL 753

  Fly   207 LTKVSRNEMGAYLCIATNGVPPSVSKRIILDVEFSPMIWV-PNQLVGAPSGTDVTIDCHTEAHPK 270
            :..|...::|.|||.|:|||...:||.:.|.|:...||.. ||..: |..|....::|.......
Mouse   754 IRHVLEEDIGYYLCQASNGVGTDISKAMFLTVKIPAMITSHPNTTI-AIKGHPKELNCTARGERP 817

  Fly   271 AIIYWVYNSVMVLPSK--KYKTDYTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRV 333
            .||.|.....::.|.:  :|.....:|.......|.::....||...:.|.:.||.||..|.|::
Mouse   818 IIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQL 882

  Fly   334 YEIPLPSTPSKQVTHTTVESRENNIIPSSRND-----------------------TTKSLQTDVG 375
            .....|..|..::..  |::|..|:..:.|.|                       :|:::...:.
Mouse   883 TVQEPPDPPELEIRE--VKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTIN 945

  Fly   376 YAMKNDLYPGSA------SSSSSGGSSSAASSSSSMQTSA------------------------- 409
            .|...||:|.|.      |.:..|.|..:...:.|.:.:|
Mouse   946 QANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAP 1010

  Fly   410 ---LPGGV-----AGNSLSSMGSKGSLAI------GKSTFYTERPPNEYAASSVAGLLLHRALLF 460
               |..||     .|...:|.||.|..:|      |.|..||.....::|...|.....:||
Mouse  1011 KKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRA--- 1072

  Fly   461 GSG 463
            |:|
Mouse  1073 GTG 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	26/93 (28%)
		Ig	145..238	CDD:416386	32/187 (17%)
		Ig strand A	145..149	CDD:409353	2/3 (67%)
		Ig strand A'	154..159	CDD:409353	4/54 (7%)
		Ig strand B	165..172	CDD:409353	1/46 (2%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	2/10 (20%)
		Ig strand F	216..223	CDD:409353	4/6 (67%)
		Ig strand G	230..238	CDD:409353	3/7 (43%)
		Ig	242..333	CDD:416386	23/93 (25%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	1/6 (17%)
		Ig strand C	272..277	CDD:409353	3/4 (75%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	0/3 (0%)
		Ig strand E	295..305	CDD:409353	2/9 (22%)
		Ig strand F	314..322	CDD:409353	1/7 (14%)
		Ig strand G	325..334	CDD:409353	4/8 (50%)
Dscaml1	NP_001074739.2	IGc2	43..110	CDD:197706
		Ig	125..218	CDD:353325
		I-set	226..311	CDD:336764
		Ig_3	317..389	CDD:339005
		Ig	408..498	CDD:353325
		IGc2	519..577	CDD:197706	18/68 (26%)
		Ig	615..681	CDD:319273	5/65 (8%)
		Ig_DSCAM	707..785	CDD:143211	23/77 (30%)
		Ig	803..891	CDD:353325	19/87 (22%)
		FN3	887..981	CDD:238020	16/95 (17%)
		FN3	988..1085	CDD:238020	19/91 (21%)
		FN3	1093..1186	CDD:238020
		FN3	1191..1282	CDD:238020
		Ig	1307..1377	CDD:319273
		FN3	1384..1474	CDD:238020
		FN3	1488..1560	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1716..1741
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1773..1803
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1840..1862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1974..2053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810