DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-delta and iglon5

DIOPT Version :9

Sequence 1:	NP_001097508.2	Gene:	DIP-delta / 5740816	FlyBaseID:	FBgn0085420	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_002938252.1	Gene:	iglon5 / 100488314	XenbaseID:	XB-GENE-945713	Length:	333	Species:	Xenopus tropicalis

Alignment Length:	347	Identity:	103/347 - (29%)
Similarity:	150/347 - (43%)	Gaps:	77/347 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IYMTNLVTHVMMDEPRFAQPIPNVTVAVGRDANLPCVVEHLGGYKVAWIHIDRQMILTIHR---H 91
            |.|...|..|...|  |..|..|.||:.|.:|.|.|:::. ...:|||  ::|..||...:   .
Frog    15 IVMLAQVLFVQCTE--FVPPADNYTVSQGDNATLSCLIDD-KVTRVAW--LNRSNILYAGKDKWS 74

  Fly    92 VISRI-------PRYSITYTDNTWLLHVNQAHQDDRGYYMC--QVNTNPMISQVGYLQVVVPPNI 147
            :.||:       ..|||..|      ||:.|   |.|.|.|  |....|..||| ||.|.||..|
Frog    75 IDSRVQLLTNTKSEYSIVIT------HVDVA---DEGLYTCSFQTEDKPHTSQV-YLIVQVPAKI 129

  Fly   148 LDIESTPSSVAVRENQNINMTCRADGFPAPKIIWRR-EDGEEIAVEKKKKVLVYDADVLPLTKVS 211
            ::|.   |||.|.|..|:|:.|.|.|.|.|.|.|:: .:|           ...:.::|.:|:::
Frog   130 VNIS---SSVTVNEGSNVNLQCLAVGKPEPTITWQQLSEG-----------FSSEGELLEITEIN 180

  Fly   212 RNEMGAYLCIATNGVPPSVSKRIILDVEFSPMIW-VPNQLVGAPSGTDVTIDCHTEAHPKAIIYW 275
            |.:.|.|.|:.:|||....:|::.:.|.:.|.|. |.|  ..:|.|...|:.|...|.|.|...|
Frog   181 RQQAGDYECVTSNGVSVPDTKKVQITVNYPPYITDVKN--AQSPVGRPATLRCKAMAVPPAEFEW 243

  Fly   276 VYNSVMVLPSKKYKTD-------------YTENSYRAHMKLTIRNLQYGDFGNYRCISKNSLGET 327
                        ||.:             .||:|:..   :...|:....:|||.|::.|.||..
Frog   244 ------------YKDEKRRLISGTEGLSIKTESSWSV---IVFSNVTSRHYGNYTCLASNKLGSF 293

  Fly   328 EGSIRVYEIPLPSTPSKQ-VTH 348
            ..|:|:.:   |..|..| .||
Frog   294 NSSLRLLK---PGDPLNQGATH 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-delta	NP_001097508.2	IG	51..143	CDD:214652	34/103 (33%)
		Ig	145..238	CDD:416386	27/93 (29%)
		Ig strand A	145..149	CDD:409353	1/3 (33%)
		Ig strand A'	154..159	CDD:409353	3/4 (75%)
		Ig strand B	165..172	CDD:409353	2/6 (33%)
		Ig strand C	178..183	CDD:409353	2/4 (50%)
		Ig strand C'	185..187	CDD:409353	0/1 (0%)
		Ig strand D	195..199	CDD:409353	0/3 (0%)
		Ig strand E	203..209	CDD:409353	1/5 (20%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	230..238	CDD:409353	1/7 (14%)
		Ig	242..333	CDD:416386	26/104 (25%)
		Ig strand A'	250..253	CDD:409353	0/2 (0%)
		Ig strand B	259..266	CDD:409353	2/6 (33%)
		Ig strand C	272..277	CDD:409353	1/4 (25%)
		Ig strand C'	281..283	CDD:409353	0/1 (0%)
		Ig strand D	289..293	CDD:409353	1/16 (6%)
		Ig strand E	295..305	CDD:409353	1/9 (11%)
		Ig strand F	314..322	CDD:409353	4/7 (57%)
		Ig strand G	325..334	CDD:409353	3/8 (38%)
iglon5	XP_002938252.1	Ig	31..123	CDD:299845	34/104 (33%)
		IG_like	35..123	CDD:214653	33/100 (33%)
		Ig	126..207	CDD:299845	28/94 (30%)
		I-set	128..207	CDD:254352	27/92 (29%)
		I-set	210..299	CDD:254352	26/105 (25%)
		Ig	227..298	CDD:143165	20/85 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10578
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4412
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265311at33208
OrthoFinder	1	1.000	-	-		FOG0000150
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970