DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34447 and LPL

DIOPT Version :9

Sequence 1:	NP_001097060.1	Gene:	CG34447 / 5740813	FlyBaseID:	FBgn0085476	Length:	389	Species:	Drosophila melanogaster
Sequence 2:	NP_000228.1	Gene:	LPL / 4023	HGNCID:	6677	Length:	475	Species:	Homo sapiens

Alignment Length:	340	Identity:	96/340 - (28%)
Similarity:	144/340 - (42%)	Gaps:	53/340 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 ILIHGY--TGDRDFAPNSYIRPVLLDHEDVYVISIDYGPLVRYPCYIQAVQNLP-------LVSR 131
            ::|||:  ||..:......:..:.....|..||.:|:        ..:|.::.|       ||.:
Human    77 MVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDW--------LSRAQEHYPVSAGYTKLVGQ 133

  Fly   132 CLAQLINNLVDRAIVANDQIHLIGFSLGGQVAGQTANYVKRKMKRITGLDPAKPLFILGPDSRRL 196
            .:|:.||.:.:......|.:||:|:|||...||...:...:|:.||||||||.|.|.......||
Human   134 DVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRL 198

  Fly   197 DKGDADFVDVIHTDVFGR-----GYLRAAGHVDFYPNFGAKQPGC---------MEENMQDPS-- 245
            ...|||||||:||...|.     |..:..||||.|||.|..||||         .|..:.|..
Human   199 SPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQL 263

  Fly   246 -SCNHERAPRFYAES-INTTVGFWARQCSGWLLQLLTLCPTTGAQAL--LGYHVSD---ELRGSY 303
             .|:|||:...:.:| :|......|.:||........||.:......  |||.::.   :.....
Human   264 VKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKM 328

  Fly   304 FLQTASKSPYALGKMQDVDNRQTLAKFHLNFDHNE--IDDDYEPQLLEAFLELEAVKVVVKMDES 366
            :|:|.|:.||.:...|        .|.|.:...:|  .:..:|..|.....|.|  .:...:.|.
Human   329 YLKTRSQMPYKVFHYQ--------VKIHFSGTESETHTNQAFEISLYGTVAESE--NIPFTLPEV 383

  Fly   367 ELDKRLNW-IYREED 380
            ..:|..:: ||.|.|
Human   384 STNKTYSFLIYTEVD 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34447	NP_001097060.1	Pancreat_lipase_like	41..309	CDD:238363	79/264 (30%)
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:30559189	32..53
		Lipase	33..473	CDD:332983	96/340 (28%)
		Essential for determining substrate specificity. /evidence=ECO:0000269\|PubMed:7592706	243..266		3/22 (14%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269\|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269\|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:26725083, ECO:0000269\|PubMed:30559189	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010