DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)41Ab and ccdc40

DIOPT Version :9

Sequence 1:	NP_001104357.1	Gene:	l(2)41Ab / 5740691	FlyBaseID:	FBgn0262123	Length:	890	Species:	Drosophila melanogaster
Sequence 2:	NP_001258742.1	Gene:	ccdc40 / 568590	ZFINID:	ZDB-GENE-060503-723	Length:	941	Species:	Danio rerio

Alignment Length:	953	Identity:	223/953 - (23%)
Similarity:	405/953 - (42%)	Gaps:	175/953 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EASPEPEELALLPPNHPLLSKFQVCLKGHLIRTKREIENEIAEIKHHVKLREQRREEQGLTLYDM 84
            |...|.||:.:|.|.|||:.:||..||.:.......:..::.|.....|...|||       :|:
Zfish    66 ENDEEEEEIVVLDPEHPLMKRFQTALKNNFTNQLERLNLDLCEKVVVEKAEAQRR-------HDL 123

  Fly    85 QQKMKFQEKQIMELSAVI-----------------EKHL---KNRQDEEFNTKTLKAENEEKIKL 129
            .:::...::.:..|.|.:                 |.||   ||:..:     |....|.:::::
Zfish   124 AEEVYMVQEMLARLQASLEVCQETNSEAAAQHRQAEDHLYVVKNQYQD-----TASQTNVQRLQV 183

  Fly   130 TKSQ--------KTLYHERMAELGDMQSLGSNIKKWACSVEDEVKNAKRIVSRDAQLQDQLSQEK 186
            .:.|        |.||         ||...|::    ||....:.||.....::   :.|..::|
Zfish   184 LELQSKVDNLALKLLY---------MQEAKSDL----CSDIKAIINASNKAQKE---RTQTEEQK 232

  Fly   187 RKSDILFYRLDIEIKK-------RENELLSICEEEATMKEVINILNMSIANANTDLEVLQNEHKR 244
            .:.||...||...::|       .:.:|:|..|:....|:       |::.|..:|:.:..||::
Zfish   233 HQQDIYVERLTNRVEKLLEQISLYDLQLISQTEQTRAAKD-------SLSEAQLELDSVIVEHRQ 290

  Fly   245 LTQAWNEVIIAIQLRDKILFQVQDAARKHREAMKHNIAGIEAIKKQIGKEMELNKKLD-SFKQRL 308
            |.|.|...::.::.||:....:|:..|:..:.|......||:.||.|.:|.|.|:.|. ...:..
Zfish   291 LLQQWKSSLLMMKRRDEAYTAMQEELRQANDQMLSLDTEIESYKKSITQEEEQNECLTLRLNRGQ 355

  Fly   309 ADETSSLRRECQDESESLLK-MQAKLDDLPEFLNTTETDL----------QDALREGSHLFTEVR 362
            .|.|:|  |:....|::|.: :||:|......|..||..|          |.||:       .:|
Zfish   356 TDCTTS--RKLITHSQNLQEVLQAQLSTYTRILQETENTLSTLHGNLEMHQSALK-------ALR 411

  Fly   363 KLDIALDKYLTQKFRTEETILRLAQDHLITDKATAYRLKLLGKSQEKRRNVDLSLSKVQNQLSLS 427
            |   .::|....:...|..|:...|:.|..:.|..|..::..|:...||..:..|.|.:|..:..
Zfish   412 K---QMEKVSAVRLDLESQIMNKLQEQLTHNNAAKYSRRMNDKTAVYRREKEAQLIKFENDFNTV 473

  Fly   428 MLEVEKLRCVVFNERAYNDSTKTKLKSAENKSSTLENGLKKIHIQIEIKMKLYEKINCKIEEMDH 492
            .||.::|...:.:..|:....:.|........|:.|..:.|....||.|.......|.||:::..
Zfish   474 TLEGQELATHLDSLLAFQAELEQKSTQRHLLLSSREEEIVKQITDIERKQATISIYNKKIKDIVS 538

  Fly   493 LFGDASGNPTDLKIKQLEKSIHIGELQVREHQQFWIMLQNHFVNLSQKRNDQLNEIQVTRKQLSI 557
            ..|.....|.::....|.|.:.....:::|.||.|:..|...|..:|::....:.:|:.:.||:|
Zfish   539 STGHEDLGPLEIHAATLSKELEEVGAKIKECQQLWLWQQGELVRFTQEKQAHSSSVQILQTQLTI 603

  Fly   558 IRQKSLKSDQELEISHRKAKELQIFIKKFTSKLELLNDKIYKKR-IHHDVE------ETEFDHEQ 615
            ::|..::.:.|:|....:..:|...||...:.:..||..:.|.. ::|.::      ||||
Zfish   604 LQQGKIRRESEMEQDQSELADLDKQIKVLMADMVKLNSLLNKNSDLNHALQQSSNLMETEF---- 664

  Fly   616 AEQTQKLKIAELEILKLEGKIVELQNEIELHKDYVIDKHRETLSWETKYKMIEETIKWAKLERSV 680
               .|:||.||.:..:.:.|:..|..|.|...:.:::..|:.:.|..:.::::||.  :.::..:
Zfish   665 ---RQRLKEAEKDSAETQLKLERLNEEKERLINSLVEAERQVMLWGKRTQLMQETC--SAIDSDI 724

  Fly   681 -KGEIGLMKTEIHRMNIRYSQLKRAQESLVLDLEHCVMHREQIFVNASVKEHLQAKFKQLKNTSQ 744
             :|:|..|:.|||||.:||:||.:.||.|:.|:|..|...:.|.|.:..:...||..:...|
Zfish   725 GQGDIRTMRAEIHRMEVRYAQLMKQQERLLRDMESVVAKSKTIAVWSEAQARTQAHKQPTHN--- 786

  Fly   745 IQVRLDEVHNRTKLISNEITFLSEKQLIDDINKI-----ERMIYMLRRIQS---DLNDIIKEDAN 801
                  :.||..:.:..:|  |..|:..::.:.:     ||:..|..|:|.   .||:|...:|.
Zfish   787 ------DYHNTIQSLRRKI--LQTKKQTEECDGVIAQLEERLGSMTSRLQDKQMHLNNIQNTEAF 843

  Fly   802 I-QD--RIEEGILAKHANLEQIIRKQMRAK---AYK--------------RLNTLKSQQVILRSE 846
            : ||  |::|   .|..||.::...|.|||   |.|              .|.|.|.::.:....
Zfish   844 LSQDLRRLQE---IKERNLYRLPVLQTRAKHLHAVKEGRYTPMATGVTALELGTHKQEERLKMVS 905

  Fly   847 LTVQQLSQKQSELNYDLTEIAKALLLDYPKKKSYVFKVLHVLN 889
            ||:|:|:|                  :||:..|    .||.:|
Zfish   906 LTLQRLAQ------------------EYPQHHS----TLHRMN 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)41Ab	NP_001104357.1	Smc	53..808	CDD:224117	186/820 (23%)
ccdc40	NP_001258742.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Smc	<93..840	CDD:224117	182/813 (22%)
		BRE1	577..674	CDD:285810	26/103 (25%)
		DUF3629	593..814	CDD:289102	59/240 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586146
Domainoid	1	1.000	113	1.000	Domainoid score	I6121
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27890
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3741
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164743at33208
OrthoFinder	1	1.000	-	-		FOG0006372
OrthoInspector	1	1.000	-	-		oto40383
orthoMCL	1	0.900	-	-		OOG6_104159
Panther	1	1.100	-	-	LDO	PTHR16275
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900