Protein Alignment CG34347 and EPB41L4B

DIOPT Version :10

• Sequence 1: NP_001368952.1
• Gene: CG34347 / 5740668
• FlyBaseID: FBgn0085376
• Length: 1519
• Species: Drosophila melanogaster
• Sequence 2: XP_011517092.1
• Gene: EPB41L4B / 54566
• HGNCID: 19818
• Length: 941
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 180/533 - (33%)
• Similarity: 250/533 - (46%)
• Gaps: 96/533 - (18%)

  Fly    14 RINLLDETEFIHEIKDDLP----GQALLDVVFARLNLIETSYFGIRYIDEENQTHWLDPASRISR 74
            |:.|||.|    |:..|||    ||.|.|.:...|:|:||.|||::::|.....||||.|..|.:
Human    88 RVFLLDGT----EVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIKK 148

  Fly    75 QLKPKSDPYDLYFGVKFYAADPCKLLEEITRYQLFLQVKQDVLQGRLPVAFELAAELGAFVVQSE 139
            |:| ....|.|:|.||:|:::|..|.||.|||...||::.|:|.|:|...:|.|.||.|..:|:|
Human   149 QMK-IGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAE 212

  Fly   140 LGDYDQRRHSKGYVSEFRLLPNQSNELETRVSELHQQLKGMSPSSAELNYLDKVKWHDMYGVDLH 204
            ||:.:...|:...|||||.:|||:..:|..:.:..::.:|.||:.|||:||:|.||.:|||||:|
Human   213 LGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMH 277

  Fly   205 PVLGEDSVEYFLGLTPSGIVVLRNKTTVAHYYWPRIAKVYYKGRYFMLRI---SDKNNELS-TYG 265
            .|.|.|..||.|||||:||::......:..::||:|.|:.:|.....|.:   .|:..|.. |:.
Human   278 VVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFV 342

  Fly   266 FETPRKSACKHLWRCCVEHHAFFRQVRVAPLPSSQSHAADLFQLGSRFRHSRPDKQTEKDAL--S 328
            |.......|||||:|.|||||||   |:....:|:|:.:|..:||||||.|   .:||..|.  |
Human   343 FRLDSARTCKHLWKCAVEHHAFF---RLRTPGNSKSNRSDFIRLGSRFRFS---GRTEYQATHGS 401

  Fly   329 AGRSPPAFTRTPSKRQPRRVIDDFFNSNGNGNGNGNGNGNGHGHGGSGAGTLGGGSHMGNRPLPQ 393
            ..|....|.|.||||.|.|....|..||                                 |:..
Human   402 RLRRTSTFERKPSKRYPSRRHSTFKASN---------------------------------PVIA 433

  Fly   394 PGMGTISN----NYDSPYRSTYSIPTSLGIRPCHQQQNNNSSSYNNNSGGNLQTPDSPRSTRSAP 454
            ..:.:.:|    ||...|..        .|.|...:.:                |.||..:...|
Human   434 AQLCSKTNPEVHNYQPQYHP--------NIHPSQPRWH----------------PHSPNVSYPLP 474

  Fly   455 WP--RSQQRSLFG--HNPSSPRSVRSASTAGGGLHHHHSHHSHGHGTSHHPHHQSSSAGATSSTS 515
            .|  .|..|..||  .|..:|     ..||..|.|||...|.|     .|.||.:.|...|....
Human   475 SPVLSSSDRLPFGIEENGGTP-----FLTAASGRHHHQHQHQH-----QHQHHSNYSLSLTLENK 529

  Fly   516 HHHRQQRASSSSA 528
            ....:...|||.:
Human   530 EGPLRSPNSSSKS 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34347	NP_001368952.1	B41	13..204	CDD:214604	83/193 (43%)
		FERM_C_NBL4_NBL5	200..289	CDD:270007	38/92 (41%)
		FA	305..347	CDD:462582	20/43 (47%)
		RSRP	596..>694	CDD:293674
EPB41L4B	XP_011517092.1	B41	87..277	CDD:214604	83/193 (43%)
		FERM_C_NBL4_NBL5	273..366	CDD:270007	39/95 (41%)
		FA	379..420	CDD:462582	20/43 (47%)