DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34347 and Ptpmeg

DIOPT Version :9

Sequence 1:	NP_001368952.1	Gene:	CG34347 / 5740668	FlyBaseID:	FBgn0085376	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster

Alignment Length:	882	Identity:	216/882 - (24%)
Similarity:	342/882 - (38%)	Gaps:	215/882 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSRIMSVRINLLDETEFIHEIKDDLPGQALLDVVFARLNLIETSYFGIRYIDEENQ-THWLDPAS 70
            |.|...|.:..||:......|:....|..|||.||..|.|.|..|||:.:..:... ..|:|...
  Fly    30 PQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQK 94

  Fly    71 RISRQLKPKSDPYD----LYFGVKFYAADPCKLLEEITRYQLFLQVKQDVLQGRLPVAFELAAEL 131
            :..:|....|...|    |.|.|||:.:||.:|.||.||||.:||:|:::|.|:||.:......|
  Fly    95 QFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLL 159

  Fly   132 GAFVVQSELGDYDQRRHSKGYVSEFRLLPNQSNELETRVSELHQQLKGMSPSSAELNYLDKVKWH 196
            .::.|||||||::...|..||:|..:||.:|:.|.|.:|.|||:..:|..|:.||.|||:..|..
  Fly   160 ASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRL 224

  Fly   197 DMYGVDLHPVLGEDSVEYFLGLTPSGIVVLRNKTTVAHYYWPRIAKVYYKGR--YFMLRISDKNN 259
            ::||:|||.....:..|..||::..|::|.::...|..:.|.::.||.:|.:  :..||.....|
  Fly   225 ELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSEN 289

  Fly   260 ELSTYGFETPRKSACKHLWRCCVEHHAFFRQVRVAPLPSSQSHAADLFQLGSRFRHS-RPDKQTE 323
            ..:..||........|.||:.|||||:|||..|    |...|...:: .|||:|.:| |.:.|..
  Fly   290 YDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR----PHRLSRFLNI-SLGSKFYYSGRTELQAV 349

  Fly   324 KDALSAGRSPPAFTRTPSKRQPRRVIDDFFNSNGNGNG------NGNGNGNGHGHG-GSGAGTLG 381
            :::...||....|.|:||||.....  ....::|:..|      :|:.:.|.|.:| .:||||:.
  Fly   350 QESKQRGRIHKVFVRSPSKRLLGAA--GGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTIL 412

  Fly   382 GGSHMGNRP------------LPQPGMGTISNNYD--------------------SPYRSTYS-- 412
            ..:.. :||            :|:......|:.||                    ||....||
  Fly   413 TITKT-SRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSG 476

  Fly   413 ------IPTSLGIRPCHQQQNNNSS--------------SYNNNSGGNLQTPDSPRSTRSAPWPR 457
                  :||::.....|||..:.|.              .:|...|.:|..|
  Fly   477 QHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLP------------- 528

  Fly   458 SQQRSLFGHNPS---SPRSVRSASTAG-GGLHHHHSHHSHGHGTSHHPHHQSSSAGATSSTSHHH 518
            .|...:..|.|:   :||......... .|...|...|...........||:|  |....|.
  Fly   529 VQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQAS--GELLLTV--- 588

  Fly   519 RQQRASSSSASHQQQRYR----SSSVESHSS---NDSRSTR----------------KHKHRHRR 560
            |.|| |:.....::..|:    |..:.|||:   .|:..|:                :::..:|:
  Fly   589 RPQR-SAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRK 652

  Fly   561 TSDNESELSRGSGRSGRSGRSHHRKHRRSHRHR-RDSAGGSDHDSTR------------------ 606
            ..|              ...:..||...:.::| ||.   |.:|.||
  Fly   653 NPD--------------LAITEARKPANAPKNRYRDI---SPYDCTRVSLVNSLTGDYINANYVN 700

  Fly   607 ----GRSYSGHRSSSMRSGSTELIDSTSQWREVQRRQAEASLGQSSVQQAAVSK----------- 656
                |.:.:.:.::.....||    :|..||.||:..:...:..::|.::...|
  Fly   701 MEIPGGAVNRYIATQGPLAST----TTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEE 761

  Fly   657 -------------------SSMVARSLHSNDSHSDTHSHHKS----RRHRKNKSPS--------- 689
                               .|.|.|.....|.|...|.||..    ..|.....|:
  Fly   762 LQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERV 826

  Fly   690 -ESRSRMWNSELAKHL-QFDLVDTEGMSEQQ---LRE 721
             .:|:|....|:.:.| |..|:|.:..:::.   :||
  Fly   827 RAARNRTLLQEIEESLKQVRLMDADADADENGGLMRE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34347	NP_001368952.1	B41	13..204	CDD:214604	74/195 (38%)
		FERM_C_NBL4_NBL5	200..289	CDD:270007	28/90 (31%)
		FA	305..347	CDD:400882	15/42 (36%)
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	74/196 (38%)
		FERM_N	38..102	CDD:286467	18/63 (29%)
		FERM_M	125..232	CDD:278785	46/106 (43%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	30/93 (32%)
		FA	333..369	CDD:285894	13/35 (37%)
		PDZ_signaling	502..589	CDD:238492	17/104 (16%)
		Y_phosphatase	666..955	CDD:278528	36/205 (18%)
		PTPc	668..955	CDD:238006	36/203 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910