Protein Alignment CG34347 and EPB41L2

DIOPT Version :10

• Sequence 1: NP_001368952.1
• Gene: CG34347 / 5740668
• FlyBaseID: FBgn0085376
• Length: 1519
• Species: Drosophila melanogaster
• Sequence 2: NP_001337228.1
• Gene: EPB41L2 / 2037
• HGNCID: 3379
• Length: 1057
• Species: Homo sapiens
• Alignment Length: 904
• Identity: 226/904 - (25%)
• Similarity: 358/904 - (39%)
• Gaps: 227/904 - (25%)

  Fly     6 RPSRIMSVRINLLDETEFIHEIKDDLPGQALLDVVFARLNLIETSYFGIRYIDEENQTHWLDPAS 70
            :.::.:..::.|||.||:..:::....||.|.|.|...|||:|..|||:.:.:...|.:|||||.
Human   213 KKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAK 277

  Fly    71 RISRQLKPKSDPYDLYFGVKFYAADPCKLLEEITRYQLFLQVKQDVLQGRLPVAFELAAELGAFV 135
            .|.|||  ::.|:...|.||||..||.:|.|:||||.|.||::||:..||||.:|...|.||::.
Human   278 EIKRQL--RNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYT 340

  Fly   136 VQSELGDYDQRRHSKGYVSEFRLLPNQSNELETRVSELHQQLKGMSPSSAELNYLDKVKWHDMYG 200
            :|:||||||...|....:|||:..|.|:.|||.:|:|||:..:|:||:.|:..:|:..|...|||
Human   341 LQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYG 405

  Fly   201 VDLHPVLGEDSVEYFLGLTPSGIVVLRNKTTVAHYYWPRIAKVYYKGRYFMLRISDKNNEL--ST 263
            ||||.....:.|:..||:..:|:::.:::..:..:.||:|.|:.||...|.:::.....|.  ||
Human   406 VDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFEST 470

  Fly   264 YGFETPRKSACKHLWRCCVEHHAFFRQVRVAPLPSSQSHAADLFQLGSRFRHS-RPDKQTEKDAL 327
            .||:.|...|.|.||:.|||||.|:|  .|:|   .|...|....|||:||:| |...||.:.:.
Human   471 IGFKLPNHRAAKRLWKVCVEHHTFYR--LVSP---EQPPKAKFLTLGSKFRYSGRTQAQTRQAST 530

  Fly   328 SAGRSPPAFTRTPSKR-------QPRRVID-----DFFNSNGNGNGNGNGNGNGHGHGGSGAGTL 380
            ...|..|.|.||.|||       .|..|:|     ||..:.|..:..|
Human   531 LIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYG----------------- 578

  Fly   381 GGGSHMGNRPLPQPGMGTISNNYDSPYRSTYSIPTSLGIRPCHQQQNNN-----SSSYNNNSGGN 440
                         ||:.:|:...|...|.....||........:.:.|:     .:.|..:|...
Human   579 -------------PGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDNIYVRHSNLM 630

  Fly   441 LQTPDSPRS----------------TRSAPWPRS---QQRSLFGHNPSSPRSVRSASTAGGGLHH 486
            |:..|..:.                ..|.|.||.   ::|.:      :|.|:::....|..|..
Human   631 LEELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRI------TPLSLQTQGRKGDHLFK 689

  Fly   487 H---------------HSHHSHGHGTSHHPHHQSSSAGATSSTSHHHRQQRASSSSASHQQQRYR 536
            .               ....:.....:..|..:....||..:.            .:||:.....
Human   690 DILSVKEKYLMPTIWTVEEKAQETDKTRAPESEGPCTGARDAV------------KSSHETLNIV 742

  Fly   537 SSSVESHSSNDSRSTRKHKHRHRRTSDNESELSRGSGRSG-RSGRSHHRKHRRSHRHRRDSAGGS 600
            .....:....|.|...:..        |..|:|.|||... |......:|...|......|:...
Human   743 EEKKRAEVGKDERVITEEM--------NGKEISPGSGPGEIRKVEPVTQKDSTSLSSESSSSSSE 799

  Fly   601 DHDSTRGRSYSGHRSSSMRSGSTELIDSTSQWRE------------VQRRQA--EAS----LGQS 647
            ..:...|.....||   :..|:   |....::.|            |:|.:|  |||    .|.|
Human   800 SEEEDVGEYRPHHR---VTEGT---IREEQEYEEEVEEEPRPAAKVVEREEAVPEASPVTQAGAS 858

  Fly   648 SVQQAAVSKSSMVARSLHSNDSHSDTHSHHKSRRHRKNKSPSESRSRMWNSELAKHLQFDLV--- 709
            .:....|.:.::.|:.:...      .|.|:....:.....:|...:..|.|:: |:..|::
Human   859 VITVETVIQENVGAQKIPGE------KSVHEGALKQDMGEEAEEEPQKVNGEVS-HVDIDVLPQI 916

  Fly   710 -----------------DTEGMSEQQLREIPYTVVETTSKRSNSNLKIHKSNSKSSVGAKSTGSG 757
                             |....:|...:|:|  :|:|.:|
Human   917 ICCSEPPVVKTEMVTISDASQRTEISTKEVP--IVQTETK------------------------- 954

  Fly   758 NTITNGSGSGNAGQARNRVDRIRGLYYQSTHPHEANGGPGAGGHAPKNGSIRSASTISS 816
             |||                      |:|.   :.:|  ||||   .:|::.:|.||:|
Human   955 -TIT----------------------YESP---QIDG--GAGG---DSGTLLTAQTITS 982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34347	NP_001368952.1	B41	13..204	CDD:214604	85/190 (45%)
		FERM_C_NBL4_NBL5	200..289	CDD:270007	32/90 (36%)
		FA	305..347	CDD:462582	18/49 (37%)
		RSRP	596..>694	CDD:293674	20/115 (17%)
EPB41L2	NP_001337228.1	PTZ00121	<9..222	CDD:173412	0/8 (0%)
		B41	220..409	CDD:214604	85/190 (45%)
		FERM_C_4_1_family	404..497	CDD:270005	34/94 (36%)
		FA	507..550	CDD:462582	17/42 (40%)
		SAB	630..670	CDD:461285	6/39 (15%)
		4_1_CTD	944..1050	CDD:461774	20/97 (21%)