DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43795 and GPR158

DIOPT Version :10

Sequence 1:NP_001097435.2 Gene:CG43795 / 5740629 FlyBaseID:FBgn0264339 Length:1420 Species:Drosophila melanogaster
Sequence 2:NP_065803.2 Gene:GPR158 / 57512 HGNCID:23689 Length:1215 Species:Homo sapiens


Alignment Length:1056 Identity:253/1056 - (23%)
Similarity:422/1056 - (39%) Gaps:241/1056 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   450 AVNRANMLTRIFKTTGRSVQEDVNLLHASVLSMVEFDDDIFAAGNCFDWNEHPAQPGLFCPFAYR 514
            |.|..|::.:..|:..:::|:|::...|.|.|::|.:..|..|...|..:...|           
Human   132 ATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFSTDSLSA----------- 185

  Fly   515 LPPPNL--------GAVFAKDLAMEYHYLGNT---SEWFFLARKNAEKVIAR---NEQYLKSFHL 565
             |.|.:        ..:..:||:....:|.|.   :|||...|:.....:.|   |:......|.
Human   186 -PAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHS 249

  Fly   566 YSNRTEERIEDDTLAVKYEDGRWSKPYYDCGGGNI---WMLTYTVPFFGYE-NGTYHFKGTSGID 626
            :..:       |.|.......:||.||.:|..|:.   |::|.:...:|.: |....|:|...:|
Human   250 WRRK-------DGLGGDKSHFKWSPPYLECENGSYKPGWLVTLSSAIYGLQPNLVPEFRGVMKVD 307

  Fly   627 IDLRRVDIDQCPQRHTPGTKRPLNIFAGTDKCKQRTTMCEAIMGLGFRRGSYKCLCRKGFYFPDI 691
            |:|::||||||...         ..|:||.||....:.|..|.||||..|:|:|:|:.|||.|.:
Human   308 INLQKVDIDQCSSD---------GWFSGTHKCHLNNSECMPIKGLGFVLGAYECICKAGFYHPGV 363

  Fly   692 VSQHKF--------FNGSLLEEEYEKLMLGKNSTYNSNSEYECLPCAEGCDSCEDSSPCIAALNW 748
            :..:.|        .:||..:.              |...|.||||.|||..|.|.|||....:.
Human   364 LPVNNFRRRGPDQHISGSTKDV--------------SEEAYVCLPCREGCPFCADDSPCFVQEDK 414

  Fly   749 PMRTSILAL--ACIVIGLLPPAAWFTFRYQQVKVVRAASPALLRVIALGAFFIYCTNIVMYPNPN 811
            .:|.:|::.  .|:::..:.....:.||  :.|.:||:...||..|..|:..:|...:::|..|:
Human   415 YLRLAIISFQALCMLLDFVSMLVVYHFR--KAKSIRASGLILLETILFGSLLLYFPVVILYFEPS 477

  Fly   812 LYTCTARIWLREIGFSLTYGALMLKTWRISVIFRVRSAKAVK-ITDAALLKRLGIICGAI----- 870
            .:.|....|.|.:||:..||.:.||..|:..:|..|:|:.:. :|...:::.|.:|...:     
Human   478 TFRCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWFLI 542

  Fly   871 ----GTCLLVRTLVSPPDVVVGRTADDLKAFLCKTDWWDYTFTSMEVLFLAWGVRLCIMVRKAPS 931
                ..|..:...:|.  :..|:|:|.|...:|..|.|||.....|.|||.|||.||..||..||
Human   543 GWTSSVCQNLEKQISL--IGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVPS 605

  Fly   932 EFNESRFISMAIYNEFLLTCFLNVSMLFLQSPANPDLLYIIFFCHTQLTVTLLLALIFGSKVYIV 996
            .|:|.|::::|::||.:::...:.....|.|....|.:.:::|.||.||||:.:.|:...|.   
Human   606 AFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPKF--- 667

  Fly   997 LRSGKSHQENIGMGTKASGAKFNFRPQVRTFA--------NPSSVTTSTVPVA-AETKLSDQEAL 1052
                 ||..|            |.|..:.|.|        ...|...|::..| :|..|..::..
Human   668 -----SHSSN------------NPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIR 715

  Fly  1053 EEIRQLSMQLQRIQEMAPPKGVAVMTISSLLDGLK-TPGGLMVVAAAAGATAQGHSAANRQSALP 1116
            :|:::|..||:..      |...::|.:..|...: :..||            |.|...|.:.:|
Human   716 DELKKLYAQLEIY------KRKKMITNNPHLQKKRCSKKGL------------GRSIMRRITEIP 762

  Fly  1117 LLALNVEMQKYSQQNNNSNGGRGSGRTSIPTMVLETPPSSTPPSAAYEERAVNTELSGDDFREQL 1181
               ..|..|...:....::.|...|    ..::.:.||.|:.          ||..|    :|:.
Human   763 ---ETVSRQCSKEDKEGADHGTAKG----TALIRKNPPESSG----------NTGKS----KEET 806

  Fly  1182 LRRTADGHIICSRCLDASKEHYYCCPPRSACDHLGSPKEEGSLSFANIKLECMCSQSEDLDQDVG 1246
            |:         :|.....|.|       |..||:....||.| |......|...:::..|:...|
Human   807 LK---------NRVFSLKKSH-------STYDHVRDQTEESS-SLPTESQEEETTENSTLESLSG 854

  Fly  1247 QR---QRRPTVRTAATNTPPTSCKRAPRNLLEAELSISYQICDNCRSKYKLTGRRRSGSYSQAQE 1308
            ::   :.:......:|.:.|..||.|..:.|.:|               |.||..|:   |..|:
Human   855 KKLTQKLKEDSEAESTESVPLVCKSASAHNLSSE---------------KKTGHPRT---SMLQK 901

  Fly  1309 NPQLGQQPAGQLPIQSRSTE----LLDRTTAAEVETEVEAR--------TKAAHSTDDIVLYSSA 1361
            :          |.:.:.:.|    |..:|..|.||...:::        |...||..|    ::.
Human   902 S----------LSVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSD----NTE 952

  Fly  1362 PEELAAQLAEPVAAP----SLGNVSSNSNNSTSGSG----GTTRPKRPDKL---------VLDLN 1409
            .::.|.|.:.|...|    ..|.:.....|.|:.:.    |||:.|  |..         |.||.
Human   953 TKDPAPQNSNPAEEPRKPQKSGIMKQQRVNPTTANSDLNPGTTQMK--DNFDIGEVCPWEVYDLT 1015

  Fly  1410 -----DRSKYTKEVSV 1420
                 ..||..|.||:
Human  1016 PGPVPSESKVQKHVSI 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43795NP_001097435.2 PDC1_MCP_like 448..629 CDD:350338 43/196 (22%)
7tmC_GPR158-like 749..998 CDD:320420 73/260 (28%)
TM helix 1 749..774 CDD:320420 3/26 (12%)
TM helix 2 786..807 CDD:320420 5/20 (25%)
TM helix 3 816..840 CDD:320420 8/23 (35%)
TM helix 4 859..879 CDD:320420 3/28 (11%)
TM helix 5 901..927 CDD:320420 13/25 (52%)
TM helix 6 935..958 CDD:320420 5/22 (23%)
TM helix 7 967..992 CDD:320420 9/24 (38%)
GPR158NP_065803.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 23..66
Cache-like region. /evidence=ECO:0000269|PubMed:34793198 85..281 35/167 (21%)
7tmC_GPR158-like 415..672 CDD:320420 75/268 (28%)
TM helix 1 415..440 CDD:320420 3/24 (13%)
TM helix 2 452..473 CDD:320420 5/20 (25%)
TM helix 3 482..506 CDD:320420 8/23 (35%)
TM helix 4 526..546 CDD:320420 2/19 (11%)
TM helix 5 575..601 CDD:320420 13/25 (52%)
TM helix 6 609..632 CDD:320420 5/22 (23%)
TM helix 7 641..666 CDD:320420 9/24 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..999 62/313 (20%)
VCPWE motif 1. /evidence=ECO:0000269|PubMed:31189666 1006..1010 0/3 (0%)
VCPWE motif 2. /evidence=ECO:0000269|PubMed:31189666 1071..1075
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1117..1164
VCPWE motif 3. /evidence=ECO:0000269|PubMed:31189666 1171..1175
Blue background indicates that the domain is not in the aligned region.

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