DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34290 and PRSS1

DIOPT Version :9

Sequence 1:	NP_001097899.2	Gene:	CG34290 / 5740609	FlyBaseID:	FBgn0085319	Length:	282	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	281	Identity:	77/281 - (27%)
Similarity:	116/281 - (41%)	Gaps:	61/281 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LHSLFIISVLESCHAVP------IVGGRIVSTVGSSTSKYPFMVSLQDVITRNTTNGVSYQHFCG 75
            ::.|.|::.:.:..|.|      ||||     .....:..|:.|||.           |..||||
Human   226 MNPLLILTFVAAALAAPFDDDDKIVGG-----YNCEENSVPYQVSLN-----------SGYHFCG 274

  Fly    76 GSLISDRWILSAAHCVWRKNI------HYIAAFIGYENIENIGQLQPYGLESVEYIYFQPSNFRN 134
            ||||:::|::||.|| ::..|      |.|....|.|...|..::       :.:..:......|
Human   275 GSLINEQWVVSAGHC-YKSRIQVRLGEHNIEVLEGNEQFINAAKI-------IRHPQYDRKTLNN 331

  Fly   135 DIALLYMKRRYWSDFGNGLQYAQLPPHGMKPDQNESCRIIGYGATHHAG---PCQKRLFEAEVRV 196
            ||.|:.:..|  :.....:....||.  ..|.....|.|.|:|.|..:|   |.:.:..:|.  |
Human   332 DIMLIKLSSR--AVINARVSTISLPT--APPATGTKCLISGWGNTASSGADYPDELQCLDAP--V 390

  Fly   197 IDNQKCRDIIGHIWAPQNG---ANTVCA--LGNNQDSCQGDSGGPLICTYGGKDYIYGLVSHGLT 256
            :...||.       |...|   :|..|.  |...:||||||||||::|    ...:.|:||.|..
Human   391 LSQAKCE-------ASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVC----NGQLQGVVSWGDG 444

  Fly   257 CGIPGMPSIYTVTRPYYDWVQ 277
            |.....|.:||....|..|::
Human   445 CAQKNKPGVYTKVYNYVKWIK 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34290	NP_001097899.2	Tryp_SPc	34..277	CDD:238113	73/256 (29%)
CG34290	NP_001097899.2	Tryp_SPc	34..276	CDD:214473	72/255 (28%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	72/256 (28%)
		Tryp_SPc	249..467	CDD:238113	73/258 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870