DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and MYOT

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_006781.1	Gene:	MYOT / 9499	HGNCID:	12399	Length:	498	Species:	Homo sapiens

Alignment Length:	241	Identity:	62/241 - (25%)
Similarity:	100/241 - (41%)	Gaps:	44/241 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 QIRDALPTDAGDYICQIATMDPREITHTVEILVPPRIHHISTGGHLQVKKGSSVRIECSATGNPM 212
            |:| :..|..||...|.|..         |...|||.  |....::.:.:|...|::...:|.|.
Human   226 QVR-SRSTSRGDVNDQDAIQ---------EKFYPPRF--IQVPENMSIDEGRFCRMDFKVSGLPA 278

  Fly   213 PNVTWSRKNNILPN--------GEEKLHSHVLSIENVDRHKGGVYICTANNRVGQPASSQVVLHV 269
            |:|:|......:.:        .|:.|||  |..|.|.....|.|.|.|.||.|: |:..|.|.|
Human   279 PDVSWYLNGRTVQSDDLHKMIVSEKGLHS--LIFEVVRASDAGAYACVAKNRAGE-ATFTVQLDV 340

  Fly   270 L-----------FSPEISVERPVVFSGEGHEATLVCIVHGETQPEVIWFK--DTMQLDTTERHIM 321
            |           :.|:   .:.|:   ||....|.|.:.....|::.|.:  :.:|.:|....:.
Human   341 LAKEHKRAPMFIYKPQ---SKKVL---EGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLY 399

  Fly   322 ETRGSRHTLIIRKVHPQDFGNYSCVAENQLG--KARKTLQLSGKPN 365
            :....|.||:|:.|:.:|.|.|:..|.|:.|  .....|.::.:||
Human   400 QDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPN 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	8/31 (26%)
		Ig	103..177	CDD:143165	7/28 (25%)
		IG_like	191..269	CDD:214653	24/85 (28%)
		IGc2	198..258	CDD:197706	20/67 (30%)
		I-set	273..360	CDD:254352	22/90 (24%)
		Ig	290..359	CDD:143165	17/72 (24%)
		FN3	<466..524	CDD:238020
MYOT	NP_006781.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..151
		Necessary for interaction with ACTN1	79..150
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..241		5/15 (33%)
		Necessary for interaction with ACTA1. /evidence=ECO:0000269\|PubMed:12499399	215..498		62/241 (26%)
		Necessary for interaction with FLNC	215..493		62/241 (26%)
		Ig	249..333	CDD:299845	25/88 (28%)
		I-set	250..340	CDD:254352	27/94 (29%)
		I-set	349..440	CDD:254352	22/96 (23%)
		Ig_Myotilin_C	366..440	CDD:143300	18/73 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45080
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010