DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34353 and USH2A

DIOPT Version :9

Sequence 1:NP_001287571.1 Gene:CG34353 / 5740590 FlyBaseID:FBgn0085382 Length:581 Species:Drosophila melanogaster
Sequence 2:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens


Alignment Length:434 Identity:80/434 - (18%)
Similarity:141/434 - (32%) Gaps:181/434 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   216 TWSRKNN----ILPNGEEKLHS------HVLSIENVDRHKG------------------------ 246
            ||::.:|    |:.|..:.:.|      ::|....::|.:|                        
Human  3506 TWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKAC 3570

  Fly   247 GVYICTANNRV------GQPAS---------SQVVLHVLFS-PE----ISVERPVVFSGEGHEAT 291
            .|..|..:::|      |.|.|         |.|.||:.:| ||    :..|..:...|:|    
Human  3571 TVAGCATSSKVVAATT
QGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKG---- 3631

  Fly   292 LVCIVHGETQPEVIWFKDTMQLDTTERHIMETRGSRHTLIIRKVHPQDFGNYS----------CV 346
               ::|               .|||:|.       :||:    ...|.:.|||          |.
Human  3632 ---LIH---------------TDTTDRR-------QHTV----TGLQPYTNYSFTLTACTSAGCT 3667

  Fly   347 -AENQLGKARKTLQLSGK-----PNVAVFNSPPISQYKDRYNISWAVDS--HSPIEEYKLSFRKL 403
             :|..||   :|||.:.:     |...:.||..:..|       |::..  :..:.:|:||..  
Human  3668 SSEPFLG---QTLQAAPEGVWVTPRHIIINSTTVELY-------WSLPEKPNGLVSQYQLSRN-- 3720

  Fly   404 PQGHEVVGNAIDSSSSSSSMSSSSSQMYGSGLHAHRIGSNMGGLSGLSGSGSY------------ 456
                   ||.: ....|...:.:...:..:..:.:::....||  |.|.|..|            
Human  3721 -------GNLL-FLGGSEEQNFTDKNLEPNSRYTYKLEVKTGG--GSSASDDYIVQTPMSTPEEI 3775

  Fly   457 ---------SGYGNVIHW---GHNDWRNVVLPAVP------------------VSHHYAQGMSYM 491
                     ..|...:.|   |      :::|.:|                  |.||    .|.:
Human  3776 YPPYNITVIGPYSIFVAWIPPG------ILIPEIPVEYNVLLNDGSVTPLAFSVGHH----QSTL 3830

  Fly   492 VRGLDPDQHYEATVQSRNRYGWSDLTNSFVFSTSSNDGPVDLST 535
            :..|.|...||..:|:..  ..|...:|.:|..:....|:||::
Human  3831 LENLTPFTQYEIRIQACQ--NGSCGVSSRMFVKTPEAAPMDLNS 3872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34353NP_001287571.1 IG_like 100..180 CDD:214653
Ig 103..177 CDD:143165
IG_like 191..269 CDD:214653 18/101 (18%)
IGc2 198..258 CDD:197706 12/81 (15%)
I-set 273..360 CDD:254352 22/101 (22%)
Ig 290..359 CDD:143165 16/79 (20%)
FN3 <466..524 CDD:238020 15/75 (20%)
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:413488
EGF_Lam 517..565 CDD:238012
EGF_Lam 574..639 CDD:238012
Laminin_EGF 641..691 CDD:395007
EGF_Lam 694..733 CDD:214543
Laminin_EGF 747..795 CDD:395007
EGF_Lam 794..844 CDD:238012
EGF_Lam 847..897 CDD:214543
EGF_Lam 900..948 CDD:238012
EGF_Lam 950..1000 CDD:238012
EGF_Lam 1001..>1037 CDD:238012
fn3 1058..1132 CDD:394996
fn3 1150..1227 CDD:394996
FN3 1242..1357 CDD:238020
FN3 1368..1451 CDD:214495
LamG 1519..1678 CDD:238058
LamG 1716..1868 CDD:238058
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020
FN3 2724..2799 CDD:238020
FN3 2818..2920 CDD:238020
FN3 2925..3015 CDD:238020
FN3 3026..>3087 CDD:238020
FN3 <3449..3494 CDD:238020
FN3 3503..3586 CDD:238020 12/79 (15%)
FN3 3590..3676 CDD:238020 27/121 (22%)
FN3 3680..3767 CDD:238020 17/105 (16%)
fn3 3777..3856 CDD:394996 15/90 (17%)
FN3 3866..3960 CDD:238020 3/7 (43%)
FN3 3964..4057 CDD:238020
fn3 4161..4247 CDD:394996
FN3 4268..4351 CDD:238020
fn3 4357..4428 CDD:394996
FN3 4444..4516 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541
FN3 4529..4627 CDD:238020
FN3 4636..4730 CDD:238020
FN3 4826..4927 CDD:238020
PDZ-binding 5200..5202
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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