DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG34353 and IGSF9

DIOPT Version :9

Sequence 1:NP_001287571.1 Gene:CG34353 / 5740590 FlyBaseID:FBgn0085382 Length:581 Species:Drosophila melanogaster
Sequence 2:NP_001128522.1 Gene:IGSF9 / 57549 HGNCID:18132 Length:1179 Species:Homo sapiens


Alignment Length:651 Identity:148/651 - (22%)
Similarity:230/651 - (35%) Gaps:225/651 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 LAIAVVSLHFESVSAQSMMTKNEPMFIS---RSETFKFITGETIVLPCEV----ANTDTYVVAWK 120
            |.:||:||    |.:|....:.:|..:|   |:       ||::||.|::    .....:|:.|.
Human     5 LGLAVLSL----VISQGADGRGKPEVVSVVGRA-------GESVVLGCDLLPPAGRPPLHVIEWL 58

  Fly   121 R-GIAI---LTAG--SVKVTPD--PRVRLVNGFNLQIRDALPTDAGDYICQIATMD--------- 168
            | |..:   :..|  |.::.||  .||||..|.:|||......|.|.|.|::..:|         
Human    59 RFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFA 123

  Fly   169 -----------PREITHTVEILVPPRIHHISTGGHLQVKKGSSVRIECSATGNPMPNVTWSRKNN 222
                       |.:...|     ||.:        |:|::...|.:.|.|.|:|:|:|||..:..
Human   124 NGSWVHLTVNSPPQFQET-----PPAV--------LEVQELEPVTLRCVARGSPLPHVTWKLRGK 175

  Fly   223 IL--PNGEEKLHSHVLSIENVDRHKGGVYICTANNRVGQPASSQVVLHVLFSPEISVERPVVFSG 285
            .|  ..|:.::.:..|.|..|:|...|||.|.|::..|. |:....|.||..|.|.|........
Human   176 DLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGS-ATHATQLLVLGPPVIVVPPKNSTVN 239

  Fly   286 EGHEATLVCIVHGETQPEVI---WFKDTMQLDTTERHIMETR----GSRHTLIIRKVHPQDFGNY 343
            ...:.:|.|  |.|..|..:   ||:|.:.:....|.....|    ||   |.:....|.|.|.|
Human   240 ASQDVSLAC--HAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGS---LRLLATQPDDAGCY 299

  Fly   344 SCVAENQL--------------------------------------------------GKARKTL 358
            :||..|.|                                                  .|..|.|
Human   300 TCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKAL 364

  Fly   359 QLSGKPN----------VAVFNSPPISQYK-DRYNISWAVDSHSPI----------------EEY 396
            ||...|.          :|:.|...:.:|. ..|| |......||:                |||
Human   365 QLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYN-SLGTAGPSPVTRVLLKAPPAFIERPKEEY 428

  Fly   397 --------------------KLSFRKLPQGHEVVGNA-IDSSSS------------------SSS 422
                                .:|:.|:.:|  :.|.| :||:||                  |::
Human   429 FQEVGRELLIPCSAQGDPPPVVSWTKVGRG--LQGQAQVDSNSSLILRPLTKEAHGHWECSASNA 491

  Fly   423 MS--SSSSQMYGSGLHAHRI----------GSNMGGLSGLSG------SGSYSGYGNVIHWGHND 469
            ::  ::|:.:|..|...|.:          |:|:....|..|      |..|:.........|:|
Human   492 VARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHD 556

  Fly   470 WRNVVLPAVPVSHHYAQGMSYMVRGLDPDQHYEATVQSRNRYGWSDLTNSFVFSTSSNDGPVDLS 534
            |.::.:| |..:|       .:|.||.|...|:.:|.::|:.|      |..||......|..|.
Human   557 WVSLAVP-VGAAH-------LLVPGLQPHTQYQFSVLAQNKLG------SGPFSEIVLSAPEGLP 607

  Fly   535 T 535
            |
Human   608 T 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34353NP_001287571.1 IG_like 100..180 CDD:214653 28/111 (25%)
Ig 103..177 CDD:143165 26/105 (25%)
IG_like 191..269 CDD:214653 25/79 (32%)
IGc2 198..258 CDD:197706 20/61 (33%)
I-set 273..360 CDD:254352 27/143 (19%)
Ig 290..359 CDD:143165 23/125 (18%)
FN3 <466..524 CDD:238020 16/57 (28%)
IGSF9NP_001128522.1 Ig 24..132 CDD:299845 29/114 (25%)
IG_like 28..110 CDD:214653 27/88 (31%)
I-set 136..223 CDD:254352 28/100 (28%)
Ig 154..220 CDD:143165 22/66 (33%)
Ig_3 226..305 CDD:290638 22/83 (27%)
IG_like 233..319 CDD:214653 21/90 (23%)
Ig 341..404 CDD:299845 12/63 (19%)
IG_like 431..503 CDD:214653 11/73 (15%)
Ig 436..500 CDD:143165 11/65 (17%)
fn3 511..596 CDD:278470 21/98 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 606..626 2/3 (67%)
FN3 625..715 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..919
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..988
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1079
PDZ-binding. /evidence=ECO:0000250 1177..1179
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.