DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and SDK2

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens

Alignment Length:	515	Identity:	122/515 - (23%)
Similarity:	202/515 - (39%)	Gaps:	88/515 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PMFISRSETFKFITGE---TIVLPCEVANTDTYVVAWKRGIAILTAGSVKVTPDPRVRLVNGFNL 147
            |.|:...|  :.||.|   .:.:||:........:.|.:..|:     |:|....|.|..|...|
Human   308 PQFVKEPE--RHITAEMEKVVDIPCQAKGVPPPSITWYKDAAV-----VEVEKLTRFRQRNDGGL 365

  Fly   148 QIRDALPTDAGDYIC--QIATMDPREITHTVEILVPPRIHHISTGGHLQ--VKKGSSVRIECSAT 208
            ||...:|.|.|.:.|  :.|..:.:..|:.....:.|.|    |.|.|.  |..|.||.:.|..:
Human   366 QISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI----TRGPLDSTVIDGMSVVLACETS 426

  Fly   209 GNPMPNVTWSRKNNILPNGEEK------LHSHVLSIENVDRHKGGVYICTANNRVG-QPASSQVV 266
            |.|.|.:||.:...||.:|..:      |.|..|.|........|.|.|.|.|..| ..||:.:|
Human   427 GAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLV 491

  Fly   267 L----HVLFSPEISVERPVVFSGEGHEATLVC-IVHGETQPEV----IWFKD--TMQLDTTERHI 320
            :    .:...|:   ::.|:   :|.:|::|| :.|   .|.|    ||.||  |:..::..|..
Human   492 VWARTRITKPPQ---DQSVI---KGTQASMVCGVTH---DPRVTIRYIWEKDGATLGTESHPRIR 547

  Fly   321 METRGSRHTLIIRKVHPQDFGNYSCVAENQLGKARKT--LQLSGKPNVAVFNSPPISQYKDR-YN 382
            ::..||.|   |.:....|.|.|:|...:..|...::  |::...|:........:|..:.| .|
Human   548 LDRNGSLH---ISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAIN 609

  Fly   383 ISWA--VDSHSPIEEYKLSFRKLPQGHEVVGNAIDSSSSSSSMSSSSSQMYGSGLHAHRIGSNMG 445
            ::|.  .|.:||:..|.|...:......|:..::|..::|.::         .||...|  |...
Human   610 LTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTV---------KGLVPAR--SYQF 663

  Fly   446 GLSGLS--GSGSYSGYGNVIHWGHNDWRNVVL----PAVPVSHHYAQG---MSYMVRGLDPDQHY 501
            .|..::  |.|.:|          .|...|.|    |..|..:..|.|   .|.|::...|.:.:
Human   664 RLCAVNDVGKGQFS----------KDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESH 718

  Fly   502 EATVQSRN--RYGWSDLTNSFVFSTSSNDGPVDLSTFLNHGLSDNEMRDLSVTFYGSSAI 559
            :..:....  ||..:.|...:.|   .|....|::..|...|......::.|..|.|:.:
Human   719 QNGILKGYIIRYCLAGLPVGYQF---KNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGL 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	19/84 (23%)
		Ig	103..177	CDD:143165	18/75 (24%)
		IG_like	191..269	CDD:214653	28/90 (31%)
		IGc2	198..258	CDD:197706	21/65 (32%)
		I-set	273..360	CDD:254352	25/95 (26%)
		Ig	290..359	CDD:143165	21/77 (27%)
		FN3	<466..524	CDD:238020	14/66 (21%)
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352
		Ig	132..210	CDD:299845
		IG_like	222..304	CDD:214653
		IGc2	233..286	CDD:197706
		I-set	308..397	CDD:254352	24/95 (25%)
		Ig	326..394	CDD:143165	17/72 (24%)
		I-set	402..492	CDD:254352	30/93 (32%)
		Ig	416..492	CDD:299845	24/75 (32%)
		Ig	502..586	CDD:299845	25/95 (26%)
		IG_like	502..586	CDD:214653	25/95 (26%)
		FN3	590..681	CDD:238020	22/111 (20%)
		FN3	693..786	CDD:238020	17/86 (20%)
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810