DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34353 and IGLON5

DIOPT Version :9

Sequence 1:NP_001287571.1 Gene:CG34353 / 5740590 FlyBaseID:FBgn0085382 Length:581 Species:Drosophila melanogaster
Sequence 2:NP_001094842.1 Gene:IGLON5 / 402665 HGNCID:34550 Length:336 Species:Homo sapiens


Alignment Length:345 Identity:99/345 - (28%)
Similarity:157/345 - (45%) Gaps:50/345 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 PGHIRDRRVGSLPHILFLAIAVVSLHFESVSAQSMMTKNEPMFISRSETFKFITGETIVLPCEVA 110
            ||    .|:..|.......:||:|....|.|.:         |.|.::.:....|:...|.|.: 
Human     6 PG----ARLRLLAAAALAGLAVISRGLLSQSLE---------FNSPADNYTVCEGDNATLSCFI- 56

  Fly   111 NTDTYV--VAWKRGIAILTAGSVKVTPDPRVRLV----NGFNLQIRDALPTDAGDYICQIATMDP 169
              |.:|  |||.....||.||:.:.|.||||||:    ..|::.|.:....|.|.|.|...|   
Human    57 --DEHVTRVAWLNRSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSFQT--- 116

  Fly   170 REITHTVEIL----VPPRIHHISTGGHLQVKKGSSVRIECSATGNPMPNVTWSR-KNNILPNGEE 229
            |...:|.::.    ||.||.:||:  .:.|.:|.:|.:.|.|.|.|.|.|||.: ::.....|| 
Human   117 RHQPYTTQVYLIVHVPARIVNISS--PVTVNEGGNVNLLCLAVGRPEPTVTWRQLRDGFTSEGE- 178

  Fly   230 KLHSHVLSIENVDRHKGGVYICTANNRVGQ-PASSQVVLHVLFSP---EISVERPVVFSGEGHEA 290
                 :|.|.::.|.:.|.|.|..:|.|.. |.|.:|::.|.:.|   :::..|..:    |..|
Human   179 -----ILEISDIQRGQAGEYECVTHNGVNSAPDSRRVLVTVNYPPTITDVTSARTAL----GRAA 234

  Fly   291 TLVCIVHGETQPEVIWFKDTMQLD--TTERHIMETRGSRHTLIIRKVHPQDFGNYSCVAENQLGK 353
            .|.|........:..|:||...|.  |.|...::|..:|..|:...|..:.:|||:|.|.|:||.
Human   235 LLRCEAMAVPPADFQWYKDDRLLSSGTAEGLKVQTERTRSMLLFANVSARHYGNYTCRAANRLGA 299

  Fly   354 ARKTLQLSGKPNVAVFNSPP 373
            :..:::|. :|. ::.||.|
Human   300 SSASMRLL-RPG-SLENSAP 317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34353NP_001287571.1 IG_like 100..180 CDD:214653 28/89 (31%)
Ig 103..177 CDD:143165 27/79 (34%)
IG_like 191..269 CDD:214653 24/79 (30%)
IGc2 198..258 CDD:197706 19/60 (32%)
I-set 273..360 CDD:254352 24/91 (26%)
Ig 290..359 CDD:143165 21/70 (30%)
FN3 <466..524 CDD:238020
IGLON5NP_001094842.1 Ig 41..129 CDD:416386 28/93 (30%)
Ig strand A' 41..46 CDD:409353 0/4 (0%)
Ig strand B 48..56 CDD:409353 2/7 (29%)
CDR1 56..60 CDD:409353 1/6 (17%)
FR2 61..68 CDD:409353 3/6 (50%)
Ig strand C 61..67 CDD:409353 3/5 (60%)
CDR2 69..79 CDD:409353 4/9 (44%)
Ig strand C' 71..74 CDD:409353 2/2 (100%)
Ig strand C' 76..79 CDD:409353 0/2 (0%)
FR3 80..115 CDD:409353 13/34 (38%)
Ig strand D 84..91 CDD:409353 4/6 (67%)
Ig strand E 94..100 CDD:409353 1/5 (20%)
Ig strand F 107..115 CDD:409353 3/7 (43%)
CDR3 116..120 CDD:409353 2/6 (33%)
Ig strand G 120..129 CDD:409353 1/8 (13%)
FR4 122..129 CDD:409353 1/6 (17%)
Ig_3 134..199 CDD:404760 23/72 (32%)
Ig strand B 148..157 CDD:409353 2/8 (25%)
Ig strand C 162..170 CDD:409353 4/7 (57%)
Ig strand F 191..199 CDD:409353 3/7 (43%)
Ig strand G 202..212 CDD:409353 3/9 (33%)
Ig_3 217..295 CDD:404760 21/81 (26%)
putative Ig strand A 218..224 CDD:409353 1/5 (20%)
Ig strand B 234..238 CDD:409353 2/3 (67%)
Ig strand C 247..251 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 1/3 (33%)
Ig strand F 288..293 CDD:409353 3/4 (75%)
Ig strand G 301..304 CDD:409353 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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