DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34353 and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	668	Identity:	140/668 - (20%)
Similarity:	242/668 - (36%)	Gaps:	241/668 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ILFLAIAVVSLHFESVSAQSMMT------KNEPMFISRSETFKFITGETIVLPCEVANTDT---- 114
            |.::|..:.|:    :|.:.::.      :.||.|::..      .||.:||.|:|.:..|
  Rat     2 IWYVATLIASV----ISTRGLVAQVAHGLREEPEFVTAR------AGEGVVLRCDVIHPVTGQPP 56

  Fly   115 -YVVAW-KRGIAI---LTAGSVKVTPDP----RVRLVNGFNLQIRDALPTDAGDYICQIATMD-- 168
             |||.| |.|:.|   :..|......||    |..|.:..:|::......|.|.|.|::..:|
  Rat    57 PYVVEWFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKVLMLDQQ 121

  Fly   169 ----------------PREITHTVEILVPPRIHHISTGGHLQVKKGSSVRIECSATGNPMPNVTW 217
                            |...|.|     ||:        :::.|:|.|:.:.|:|.|||.|.|||
  Rat   122 YDTFHNGSWVHLTINAPPTFTET-----PPQ--------YIEAKEGGSITMTCTAFGNPKPIVTW 173

  Fly   218 SRKNNIL-PNGEEKLHSHVLSIENVDRHKGGVYICTANNRVGQPASSQVVLHVLF-SPEISVERP 280
            .::..:| .:|:.::....|::.:|.|...|.|.|.|.:..|:...:   .|:|. .|...|..|
  Rat   174 LKEGTLLSASGKYQVSDGSLTVTSVSREDRGAYTCRAYSIQGEAVHT---THLLVQGPPFIVSPP 235

  Fly   281 V-VFSGEGHEATLVCIVHGETQP-----------EVIWFKDTMQLDTTERHIMETRGSRHTLIIR 333
            . :......:|.|.|  ..|..|           |.::|::.::|..  |.:::     .||||.
  Rat   236 ENITVNISQDALLTC--RAEAYPGNLTYTWYWQDENVYFQNDLKLRV--RILID-----GTLIIF 291

  Fly   334 KVHPQDFGNYSCVAENQLGK-----ARKTLQLSGKPNVAVFNSPP-------------------- 373
            :|.|:|.|.|:||..|.||:     |..|:|...:    |.|.||
  Rat   292 RVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPAR----VLNMPPVIYVPVGIHGYIRCPVDAEP 352

  Fly   374 ----ISQYKD------RYNISWAV--DSHSPIE-------------------------------- 394
                :...||      ..|:.|.:  |....||
  Rat   353 PATVVKWNKDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCVPYNTLGTMGQSAPARLVLK 417

  Fly   395 -----------EYK--------------------LSFRK-----------LPQG----------- 406
                       ||:                    :::||           ||.|
  Rat   418 DPPYFTVLPGWEYRQEAGRELLIPCAAAGDPFPVITWRKVGKPSRSKHNALPSGSLQFRALSKED 482

  Fly   407 HE----VVGNAIDSSSSSSSMSSSSSQMYGSG---LHAHRIGSNMGGLSGLSGSGSYS---GYGN 461
            |.    |..|.:.|.::|:.::...:..:..|   :|.....:|:....|..|....:   .||.
  Rat   483 HGEWECVATNVVTSITASTHLTVIGTSPHAPGSVRVHVSMTTANVSWEPGYDGGYEQTFSVWYGP 547

  Fly   462 VI---HWGHNDWRNVVLPAVPVSHHYAQGMSY-MVRGLDPDQHYEATVQSRNRYGWSDLT----- 517
            ::   .:|.:||.::.:|.         |.|: :|..|:|:..|:.:|.::||.|.|..:
  Rat   548 LMKRAQFGPHDWLSLSVPL---------GPSWLLVDSLEPETAYQFSVLAQNRLGTSAFSEVVTV 603

  Fly   518 NSFVFSTSSNDGPVDLST 535
            |:..|..::.: |:.|.|
  Rat   604 NTLAFPVTTPE-PLVLVT 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	28/110 (25%)
		Ig	103..177	CDD:143165	26/104 (25%)
		IG_like	191..269	CDD:214653	22/78 (28%)
		IGc2	198..258	CDD:197706	20/60 (33%)
		I-set	273..360	CDD:254352	28/103 (27%)
		Ig	290..359	CDD:143165	25/84 (30%)
		FN3	<466..524	CDD:238020	17/63 (27%)
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332
		Ig	41..115	CDD:319273	22/73 (30%)
		I-set	139..225	CDD:369462	27/101 (27%)
		Ig	229..321	CDD:386229	26/100 (26%)
		Ig	<353..414	CDD:386229	7/60 (12%)
		Ig	438..502	CDD:319273	10/63 (16%)
		FN3	510..605	CDD:238020	22/103 (21%)
		FN3	621..703	CDD:238020	140/668 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810