DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34353 and kirre

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	120/594 - (20%)
Similarity:	197/594 - (33%)	Gaps:	167/594 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 HSNSKQNSKTGKMAAEARTISKPGHIRDRRVGSLPHILFLAIAVVSLHFESVSAQSMMTKNEPM- 87
            |:.||:|..           |:..|..|....|       :.:..|....|.:|.|...:::|.
  Fly    30 HAKSKKNKS-----------SQSSHHGDSSSSS-------SSSSSSSGSSSAAASSANDESKPKG 76

  Fly    88 -------FISRSETFKFITGETIVLPCEVANTDTYVVAWKRGIAILTAGSVKVTPD--------- 136
                   |....:....:.|..:.|||.|..               ..|:::.|.|
  Fly    77 GDNGGQHFAMEPQDQTAVVGSRVTLPCRVME---------------KVGALQWTKDDFGLGQHRN 126

  Fly   137 ----PRVRLVNG-----FNLQIRDALPTDAGDYICQI-----ATMDPREITHTVEILVPPRIHHI 187
                .|..:|..     |:|.|...:..|...|.||:     .....|.....:.:||||....|
  Fly   127 LSGFERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAPKI 191

  Fly   188 STGGHLQVKKGSSVRIEC-SATGNPMPNVTW-SRKNNILPNGEEKLHS-----------HVLSIE 239
            :.|.:|...:...:.:|| |..|.|...:|| ....|:|..|.|.:..           .:|.:.
  Fly   192 TQGDYLVTTEDREIELECVSQGGKPAAEITWIDGLGNVLTKGIEYVKEPLADSRRITARSILKLA 256

  Fly   240 NVDRHKGGVYICTANNRVGQP-ASSQVVLHVLFSPEISVERPVVFSG--------EGHEATLVCI 295
            ....|....:.|.|.|...:. .|::::|.|.::|::.|.   |..|        ||.|..|.|
  Fly   257 PKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVS---VVGGALAGGKIPEGAEVILSC- 317

  Fly   296 VHGETQPEVI---WF--KDTMQLD-TTERHIMETRGSRHTLIIRKVHPQDFGNYSCVAENQLGKA 354
             ..:..|..:   ||  .:.|..| ||:..|.......|..|::           |...|.:||:
  Fly   318 -QADANPHELSYRWFINDELMTGDFTTKMIIHNVSRQYHDAIVK-----------CEVVNAVGKS 370

  Fly   355 R--KTLQLSGKPNVAVFNSPPISQYKD---------------RYNISWAVDSHSPI----EEYKL 398
            .  |.|.:|..|   ||...|:|...|               ...|.|..::...:    .|.||
  Fly   371 EQSKKLDISFGP---VFRQRPVSVEADLGATVSMRCDVAGNPEPEIEWISENSDQVVGVAAELKL 432

  Fly   399 SFRKLPQGH---EVVGNAIDSSSSSSSMSSSSSQMYGSGLHAHRIGSNMGGLSG------LSGSG 454
            .......|.   :.|.|......:.:::....:.:    :.:|::  ..||:.|      |:.|.
  Fly   433 KVSSETAGRYFCKAVVNGFPEIGAEATLYVKRAPI----ITSHKV--QFGGVGGRVKIDCLAFSI 491

  Fly   455 S------YSGYGNVIHWGHNDWRNVVLPAVPV--SHHYAQGM--SYMVRGLDPDQ--HYEATVQS 507
            .      :|..|.:|:....|      |.:.:  .||..:|:  :.::|......  .|..||.
  Fly   492 PKAEHILWSFEGKIINMSSAD------PDIYIFEEHHLPEGVRAALIIRDSKATHFGKYNCTVM- 549

  Fly   508 RNRYGWSDL 516
             |.||...|
  Fly   550 -NSYGGDSL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	18/102 (18%)
		Ig	103..177	CDD:143165	17/96 (18%)
		IG_like	191..269	CDD:214653	19/91 (21%)
		IGc2	198..258	CDD:197706	16/72 (22%)
		I-set	273..360	CDD:254352	25/102 (25%)
		Ig	290..359	CDD:143165	17/76 (22%)
		FN3	<466..524	CDD:238020	13/57 (23%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845	18/110 (16%)
		IG_like	88..182	CDD:214653	18/108 (17%)
		C2-set_2	189..279	CDD:285423	19/89 (21%)
		Ig_2	307..379	CDD:290606	21/84 (25%)
		I-set	382..462	CDD:254352	14/82 (17%)
		IGc2	396..446	CDD:197706	6/49 (12%)
		Ig	466..561	CDD:299845	22/106 (21%)
		IG_like	478..561	CDD:214653	19/88 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810