DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and Kirrel1

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_006232737.1	Gene:	Kirrel1 / 310695	RGDID:	727883	Length:	805	Species:	Rattus norvegicus

Alignment Length:	619	Identity:	118/619 - (19%)
Similarity:	228/619 - (36%)	Gaps:	132/619 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QNSKTGKMAAEARTISKPGHIRDRRVGSLPHILFLAIAVVSLHFESVSAQSMMTKNEPMFISRSE 93
            :|..|..|..::..:.|......:::.: ||::...:..|:|.......|:..:: ||    ..:
  Rat     4 ENRSTCLMTCQSSLLPKKPRFLSQKMWA-PHLVVAYLIFVTLALALPGTQTRFSQ-EP----ADQ 62

  Fly    94 TFKFITGETIVLPCEVANTDTYVVAW-KRGIAILTAGSVKVTPDPRVRLVNG-----FNLQIRDA 152
            |  .:.|...||||.:.|. :.:|.| |.|:|:.....:|..  ||.|:|..     :||:|.||
  Rat    63 T--VVAGHRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAW--PRYRVVGSADAGQYNLEITDA 122

  Fly   153 LPTDAGDYICQIATMDPREITHTVEILVPPRIHHISTGGHLQVKKGSSVRIECSA-TGNPMPNVT 216
            ..:|...|.||......|.....:.:|:||....|..|..:.::.|:...:.|.| ...|...:.
  Rat   123 ELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPYNLTCRAFNAKPAATII 187

  Fly   217 WSR----------KNNILPNGEEKLHSHVLSIENVDRHKGGVYICTANNRV---GQPASSQVVLH 268
            |.|          ...:|.:|:.:.....|.|:..|...|.|:.|.:.|..   |:..|.::.:|
  Rat   188 WFRDGTQQEGAVTSTELLKDGKRETTISQLLIQPTDLDIGRVFTCRSMNEAIPNGKETSIELDVH 252

  Fly   269 VLFSPEISVERPVVFSGEGHEATLVCIVHGETQPEVI---WFKDTMQLDTTERHIMETRGSRHTL 330
            ...:..:|:|...|..||    .::........||::   |.|....::.......||.
  Rat   253 HPPTVTLSIEPQTVLEGE----RVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETN------ 307

  Fly   331 IIRKVHPQDFGNY----SCVAENQLGKARKT--LQLSGKPNVAVFNSPPISQYKDRYNISWAVDS 389
                   .|:..:    ||...|::|....:  :.:...|.:.|:..|..:.......::.....
  Rat   308 -------VDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCVWVG 365

  Fly   390 HSPIEEYKLSFRKLP--QGHEVVGNAIDSSSSSSSMSSSSSQMYGSGLHAHRIGSNMGGLSGLSG 452
            :.|:   .|::.|..  .|..:.|:..:::.|:..:|:|:..:..|...|              .
  Rat   366 NPPL---TLTWTKKDSNMGPRLPGSPPEANLSAQVLSNSNQLLLKSVTQA--------------D 413

  Fly   453 SGSYSGYGNVIHWGHNDWRNVVLPAVPVSHH----YAQG--------MSYMVRGLDPD----QHY 501
            :|:|:             ...::|.:.|:..    |..|        :.:.|||   |    :.:
  Rat   414 AGTYT-------------CRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRG---DGGKVECF 462

  Fly   502 EATVQSRNRYGWSDLTNSFVFST-------SSNDGPVDLSTFLNHGLSDNEMRDLSVTFYGSSAI 559
            ..:....:|..|:...|.....|       .:|.|...|||...:.:.:.:.:    |.|..:|.
  Rat   463 IGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQ----THYNCTAW 523

  Fly   560 N-------------RQKLGLLALSSATLALSLLV 580
            |             |:.|.:..::.||:...:|:
  Rat   524 NSFGPGTAIIQLEEREVLPVGIIAGATIGAGILL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	26/85 (31%)
		Ig	103..177	CDD:143165	25/79 (32%)
		IG_like	191..269	CDD:214653	17/91 (19%)
		IGc2	198..258	CDD:197706	15/73 (21%)
		I-set	273..360	CDD:254352	16/95 (17%)
		Ig	290..359	CDD:143165	11/77 (14%)
		FN3	<466..524	CDD:238020	11/73 (15%)
Kirrel1	XP_006232737.1	I-set	54..148	CDD:254352	29/103 (28%)
		Ig	57..148	CDD:299845	29/100 (29%)
		Ig2_KIRREL3-like	170..251	CDD:143236	16/80 (20%)
		I-set	255..336	CDD:254352	16/97 (16%)
		Ig_2	259..337	CDD:290606	16/94 (17%)
		Ig_2	340..437	CDD:290606	17/126 (13%)
		IG_like	346..437	CDD:214653	15/120 (13%)
		Ig5_KIRREL3	439..536	CDD:143306	18/103 (17%)
		IG_like	451..536	CDD:214653	17/91 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900