DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	113/501 - (22%)
Similarity:	190/501 - (37%)	Gaps:	109/501 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 KFITGETIVLPCEVANTDTYVVAWKRGIAILTAGSVKVTPDPRVRLVNGFNLQIRDALPTDAGDY 160
            :|..||...:.|.|:::....|:|     :.....|...||.|..::...||||.:...:|.|.|
  Rat   125 EFKQGEDAEVVCRVSSSPAPAVSW-----LYHNEEVTTIPDNRFAVLANNNLQILNINKSDEGIY 184

  Fly   161 ICQ-----IATMDPREITHTVEILVPPRIHHISTGGHLQVKKGSSVRIECSATGNPMPNVTWSRK 220
            .|:     ...:|.|:|  .|.:.|||.|.......:...::|..:.:.|.|:|:|.|.::|.|.
  Rat   185 RCEGRVEARGEIDFRDI--IVIVNVPPAIVMPQKSFNATAERGEEMTLTCKASGSPDPAISWFRN 247

  Fly   221 NNILPNGEE---KLHSHVLSIENVDRHKGGVYICTANNRVGQPASSQVVLHVLFSPEISVERPVV 282
            ..::...|:   |..:..|::.|:....||.|:|.|.|:.|:. ..|..|.|...|.|...:...
  Rat   248 GKLIEENEKYILKGSNTELTVRNIINKDGGSYVCKATNKAGED-QKQAFLQVFVQPHILQLKNET 311

  Fly   283 FSGEGHEATLVCIVHGETQPEVIWFK--DTMQL---DTTERHIMETRG--SRHTLIIRKVHPQDF 340
            .|..|| .||:|...||..||:.|.:  |.:..   |.:....:|.:|  .|.:|.||.|...|.
  Rat   312 TSENGH-VTLICEAEGEPVPEITWKRAIDGVTFSEGDKSPDGRIEVKGQHGRSSLHIRDVKLSDS 375

  Fly   341 GNYSCVAENQLGKARKTLQL------------------SGKP-NVA--VFNSPPISQY------- 377
            |.|.|.|.:::|..::::.|                  .|.| |::  |..:||.|.:
  Rat   376 GRYDCEAASRIGGHQRSMHLDIEYAPKFVSNQTMYYSWEGNPINISCDVKANPPASIHWRREKLV 440

  Fly   378 ---------------------------KD--RYNISWAVDSHSPIEEYKLSFRKLPQGHEVVGNA 413
                                       .|  |||.:......:..:||.|....:|.....| ..
  Rat   441 LPAKNTTHLKTHSVGRKMILEIAPTSDNDFGRYNCTATNRIGTRFQEYILELADVPSSPRGV-KI 504

  Fly   414 IDSSSSSSSMSSSSSQMYGSGLHAHRIGSNMGGLSGLSGSGSYSGYGNVIHWGHNDWRNVVLPAV 478
            |:.|.:::.:|.:..:.:|                           |..||....|.:.|.....
  Rat   505 IELSQTTAKISFNKPESHG---------------------------GVPIHHYQVDVKEVTSETW 542

  Fly   479 PVSHHYAQGMSYMVRGLDPDQHYEATVQSRNRYGWSDLTNSFVFST 524
            .:...:....:.::..|:|:..||..|.:.|..|..|.:...:|.|
  Rat   543 KIVRSHGVQTTVVLSSLEPNTTYEVRVAAVNGKGQGDYSKIEIFQT 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	22/84 (26%)
		Ig	103..177	CDD:143165	19/78 (24%)
		IG_like	191..269	CDD:214653	21/80 (26%)
		IGc2	198..258	CDD:197706	18/62 (29%)
		I-set	273..360	CDD:254352	28/93 (30%)
		Ig	290..359	CDD:143165	23/75 (31%)
		FN3	<466..524	CDD:238020	11/57 (19%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452
		Ig strand B	38..42	CDD:409452
		Ig strand C	50..54	CDD:409452
		Ig strand E	76..80	CDD:409452
		Ig strand F	90..95	CDD:409452
		Ig strand G	104..107	CDD:409452
		IGc2	128..189	CDD:197706	18/65 (28%)
		Ig strand B	130..139	CDD:409353	2/8 (25%)
		Ig strand C	145..153	CDD:409353	2/12 (17%)
		Ig strand C'	156..159	CDD:409353	0/2 (0%)
		Ig strand D	162..167	CDD:409353	1/4 (25%)
		Ig strand E	168..175	CDD:409353	4/6 (67%)
		IgI_1_MuSK	209..298	CDD:409562	23/89 (26%)
		Ig strand B	228..232	CDD:409562	0/3 (0%)
		Ig strand C	241..245	CDD:409562	0/3 (0%)
		Ig strand E	264..268	CDD:409562	1/3 (33%)
		Ig strand F	278..283	CDD:409562	2/4 (50%)
		Ig strand G	291..294	CDD:409562	0/2 (0%)
		Ig	300..397	CDD:416386	29/97 (30%)
		Ig strand A	300..305	CDD:409353	1/4 (25%)
		Ig strand A'	309..313	CDD:409353	0/3 (0%)
		Ig strand B	317..325	CDD:409353	4/8 (50%)
		Ig strand C	331..337	CDD:409353	2/5 (40%)
		Ig strand C'	340..343	CDD:409353	0/2 (0%)
		Ig strand D	353..359	CDD:409353	1/5 (20%)
		Ig strand E	362..368	CDD:409353	2/5 (40%)
		Ig strand F	376..384	CDD:409353	4/7 (57%)
		Ig strand G	387..397	CDD:409353	2/9 (22%)
		Ig_3	401..479	CDD:404760	11/77 (14%)
		Ig strand B	418..422	CDD:409353	1/3 (33%)
		Ig strand C	431..435	CDD:409353	1/3 (33%)
		Ig strand E	458..462	CDD:409353	0/3 (0%)
		Ig strand F	472..477	CDD:409353	3/4 (75%)
		Ig strand G	486..489	CDD:409353	1/2 (50%)
		FN3	496..588	CDD:238020	20/119 (17%)
		fn3	594..678	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810