DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34353 and SIGLEC15

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_998767.1	Gene:	SIGLEC15 / 284266	HGNCID:	27596	Length:	328	Species:	Homo sapiens

Alignment Length:	200	Identity:	46/200 - (23%)
Similarity:	74/200 - (37%)	Gaps:	43/200 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GETIVLPCEVANTDTY-----VVAWKRG---------------------IAILTAGSVKVTPDPR 138
            |:..||||...:...:     ...|:.|                     .|:...|..::..:||
Human    57 GDAAVLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSELCQTALSLHGRFRLLGNPR 121

  Fly   139 VRLVNGFNLQIRDALPTDAGDYICQIA----TMDPREITHTVEILV--PPRIHHISTGGHLQVKK 197
               .|..:|::......|...|.|::.    ..|..|..|.|.:.|  .|||.:||    :....
Human   122 ---RNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGVRLHVTAAPRIVNIS----VLPSP 179

  Fly   198 GSSVRIECSATGNPMPNVTWSRK---NNILP-NGEEKLHSHVLSIENVDRHKGGVYICTANNRVG 258
            ..:.|..|:|.|.|.|.:.||..   |::.. ....:.|.|:::.|.......|.|.|||.|.:|
Human   180 AHAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGHGHLVTAELPALTHDGRYTCTAANSLG 244

  Fly   259 QPASS 263
            :..:|
Human   245 RSEAS 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	20/109 (18%)
		Ig	103..177	CDD:143165	18/103 (17%)
		IG_like	191..269	CDD:214653	19/76 (25%)
		IGc2	198..258	CDD:197706	18/63 (29%)
		I-set	273..360	CDD:254352
		Ig	290..359	CDD:143165
		FN3	<466..524	CDD:238020
SIGLEC15	NP_998767.1	Ig	44..150	CDD:299845	16/95 (17%)
		Ig	<187..252	CDD:299845	18/62 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910