DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34353 and Dscam4

DIOPT Version :9

Sequence 1:	NP_001287571.1	Gene:	CG34353 / 5740590	FlyBaseID:	FBgn0085382	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster

Alignment Length:	594	Identity:	130/594 - (21%)
Similarity:	208/594 - (35%)	Gaps:	162/594 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 CEVANTDTYVVAWKR-GIAILTAGSVKVTPDPRVRLVNGFNLQIRDALPTDAGDYICQIATMDPR 170
            |.|:....:.|.|.. |..||....|::..|| .||:      |:.....|.|.|.|.::. :..
  Fly   351 CIVSGHPVHDVNWLHDGKPILRDNRVEILTDP-PRLI------IKKVQKEDPGMYQCFVSN-EWE 407

  Fly   171 EITHTVEILV----PPRIHHISTGGHLQVKKGSSVRIECSATGNPMPNVTWSRKNNILPNGEE-- 229
            :|..|.|:.:    |..::..|   ...::.|.:|.::|.|||||:|..|||.....:|:...
  Fly   408 QIQSTAELQLGDASPELLYWFS---EQTLQPGPTVSLKCVATGNPLPQFTWSLDGFPIPDSSRFL 469

  Fly   230 -----KLHSHVLS---IENVDRHKGGVYICTANNRVGQPASSQVVLHVLFSPEISVERPVVFSGE 286
                 .:|..|:|   |.||....||.|.|||.|.:|:.:.|..| ::...|.|. |.|.:....
  Fly   470 VGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKV-NIYGLPYIR-EMPKITGIS 532

  Fly   287 GHEATLVCIVHGETQPEVIWFKDTMQLDTTERHIMETRGSRHTLIIRKVHP-QDFGNYSCVAEN- 349
            |.:..:.|.|.|....::.|.:|...|....|......|   ||||.::.. :|.|.|:|:|:|
  Fly   533 GSDLIVKCPVAGYPIDKIHWERDGQTLPINRRQRAYNNG---TLIIEQLQRLEDAGTYTCMAQNK 594

  Fly   350 --QLGKARKTLQLSGKPNVAVFNSPPISQYKD--RYNISWAVDSHSPIEEYKLSFRKLPQGHEVV 410
              |..:....:|:...|.:.     ||....:  |..:..|:.......:..:|||....|..::
  Fly   595 QKQTSRRNVEIQVLVPPKIM-----PIQAMTNMLREGMRAAISCQILEGDLPVSFRWERNGKPLI 654

  Fly   411 GNA------IDSSSSS---SSMSSSSSQMYGSGLHAHRIGSNMGGLSGLS--------------- 451
            |..      :|..|:|   ..:||..|..|..      |.||:.|....:
  Fly   655 GTGNEVFRRLDEYSASLVIEHISSDHSGNYTC------IASNVAGTERFTVPLTVNVPPKWILEP 713

  Fly   452 -GSGSYSGYGNVIHWGHN-------DWRNVVLPAVPVSHHYAQGMSYMVRGLDPDQHYEATVQ-- 506
             .|.:.:|...::|...:       .|:..:.|               ..|...|..||.|||
  Fly   714 KDSSAQAGADVLLHCQSSGYPTPTITWKKAIGP---------------TPGEYKDFLYEPTVQLF 763

  Fly   507 ---------------------SRNRYGWSDLTNSFV-------FSTSS----------------- 526
                                 ::|..|.......|:       |.|.:
  Fly   764 PNGTIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNV 828

  Fly   527 -NDGPVDL-------STFLNHGLS------DNEMRDLSVTFYGSSAINRQKLGLL------ALSS 571
             .|.|:|.       ..:|:..|.      |..:.|..|:..|.|...||..|:.      |...
  Fly   829 QGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQ 893

  Fly   572 ATLALSLLV 580
            ..:::.|:|
  Fly   894 DEMSIQLIV 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34353	NP_001287571.1	IG_like	100..180	CDD:214653	20/73 (27%)
		Ig	103..177	CDD:143165	19/70 (27%)
		IG_like	191..269	CDD:214653	29/87 (33%)
		IGc2	198..258	CDD:197706	26/69 (38%)
		I-set	273..360	CDD:254352	24/90 (27%)
		Ig	290..359	CDD:143165	19/72 (26%)
		FN3	<466..524	CDD:238020	13/94 (14%)
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549	20/73 (27%)
		Ig strand B	347..351	CDD:409549	130/594 (22%)
		Ig strand C	360..364	CDD:409549	1/3 (33%)
		Ig strand E	383..387	CDD:409549	2/9 (22%)
		Ig strand F	397..402	CDD:409549	2/4 (50%)
		Ig strand G	410..413	CDD:409549	0/2 (0%)
		IgI_4_Dscam	422..516	CDD:409548	31/97 (32%)
		Ig strand B	439..443	CDD:409548	1/3 (33%)
		Ig strand C	452..456	CDD:409548	1/3 (33%)
		Ig strand E	482..486	CDD:409548	1/3 (33%)
		Ig strand F	496..501	CDD:409548	2/4 (50%)
		Ig strand G	509..512	CDD:409548	0/2 (0%)
		IgI_5_Dscam	520..607	CDD:409550	24/90 (27%)
		Ig strand B	536..540	CDD:409550	0/3 (0%)
		Ig strand C	549..553	CDD:409550	0/3 (0%)
		Ig strand E	571..575	CDD:409550	3/6 (50%)
		Ig strand F	586..591	CDD:409550	2/4 (50%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	21/103 (20%)
		Ig strand A	611..613	CDD:409353	1/1 (100%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	1/8 (13%)
		Ig strand C	641..648	CDD:409353	3/6 (50%)
		Ig strand C'	650..652	CDD:409353	1/1 (100%)
		Ig strand D	659..664	CDD:409353	0/4 (0%)
		Ig strand E	668..675	CDD:409353	2/6 (33%)
		Ig strand F	682..690	CDD:409353	2/13 (15%)
		Ig strand G	693..702	CDD:409353	1/8 (13%)
		IgI_7_Dscam	706..801	CDD:409546	15/109 (14%)
		Ig strand B	724..728	CDD:409546	0/3 (0%)
		Ig strand C	737..741	CDD:409546	0/3 (0%)
		Ig strand E	766..770	CDD:409546	0/3 (0%)
		Ig strand F	780..785	CDD:409546	0/4 (0%)
		Ig strand G	794..797	CDD:409546	0/2 (0%)
		Ig	818..904	CDD:416386	16/85 (19%)
		putative Ig strand B	820..827	CDD:409353	0/6 (0%)
		putative Ig strand C	835..841	CDD:409353	1/5 (20%)
		putative Ig strand C'	853..856	CDD:409353	0/2 (0%)
		putative Ig strand D	862..866	CDD:409353	1/3 (33%)
		putative Ig strand E	868..874	CDD:409353	1/5 (20%)
		putative Ig strand F	881..889	CDD:409353	1/7 (14%)
		putative Ig strand G	892..902	CDD:409353	1/9 (11%)
		FN3	906..999	CDD:238020
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810